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Comment
. 2021 Jan;11(1):12.
doi: 10.1158/2159-8290.CD-RW2020-168. Epub 2020 Nov 20.

IFITM3 Enhances PI3K Pathway Signaling to Promote B-cell Malignancies

No authors listed
Comment

IFITM3 Enhances PI3K Pathway Signaling to Promote B-cell Malignancies

No authors listed. Cancer Discov. 2021 Jan.

Abstract

Pre-B cells in Ifitm3 -/- mice were less able to transform into B-cell cancers than in wild-type mice.

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Comment on

  • IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells.
    Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. Lee J, et al. Nature. 2020 Dec;588(7838):491-497. doi: 10.1038/s41586-020-2884-6. Epub 2020 Nov 4. Nature. 2020. PMID: 33149299 Free PMC article.

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