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Review
. 2020 Dec;12(12):1102-1114.
doi: 10.1038/s41557-020-00587-w. Epub 2020 Nov 20.

Metabolic glycan labelling for cancer-targeted therapy

Hua Wang  1   2   3 , David J Mooney  4   5
Affiliations
Review

Metabolic glycan labelling for cancer-targeted therapy

Hua Wang et al. Nat Chem. 2020 Dec.

Abstract

Metabolic glycoengineering with unnatural sugars provides a powerful tool to label cell membranes with chemical tags for subsequent targeted conjugation of molecular cargos via efficient chemistries. This technology has been widely explored for cancer labelling and targeting. However, as this metabolic labelling process can occur in both cancerous and normal cells, cancer-selective labelling needs to be achieved to develop cancer-targeted therapies. Unnatural sugars can be either rationally designed to enable preferential labelling of cancer cells, or specifically delivered to cancerous tissues. In this Review Article, we will discuss the progress to date in design and delivery of unnatural sugars for metabolic labelling of tumour cells and subsequent development of tumour-targeted therapy. Metabolic cell labelling for cancer immunotherapy will also be discussed. Finally, we will provide a perspective on future directions of metabolic labelling of cancer and immune cells for the development of potent, clinically translatable cancer therapies.

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References

    1. Ferlay, J. et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int. J. Cancer 144, 1941–1953 (2019).
    1. Bray, F. et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424 (2018).
    1. Shapiro, C. L. & Recht, A. Side effects of adjuvant treatment of breast cancer. N. Engl. J. Med. 344, 1997–2008 (2001). - PubMed
    1. Baskar, R., Lee, K. A., Yeo, R. & Yeoh, K.-W. Cancer and radiation therapy: current advances and future directions. Int. J. Med. Sci. 9, 193 (2012). - PubMed - PMC
    1. Maeda, H., Greish, K. & Fang, J. in Polymer therapeutics II 103–121 (Springer, 2006).

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