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. 2021 Feb;50(1):36-45.
doi: 10.1111/jmp.12501. Epub 2020 Nov 20.

Safety and immunogenicity of 17DD attenuated yellow fever vaccine in howler monkeys (Alouatta spp.)

André Tavares da Silva Fernandes  1 , Silvia Bahadian Moreira  2 , Luciane Pinto Gaspar  1 , Marisol Simões  1 , Ana Carolina Dos Reis Albuquerque Cajaraville  1 , Renata Carvalho Pereira  1 , Mariana Pierre de Barros Gomes  1 , José Henrique Rezende Linhares  1 , Vanessa de Oliveira Santos  1 , Renata Tourinho Santos  1 , Juliana Fernandes Amorim  1 , Tamiris Azamor da Costa Barros  1 , Juliana Gil Melgaço  1 , Andréa Marques Vieira da Silva  1 , Camilla Bayma Fernandes  1 , Luciana Neves Tubarão  1 , Jane da Silva  1 , Elena Cristina Caride  1 , Maria Beatriz Borges  1 , Rosane Cuber Guimarães  1 , Renato Sérgio Marchevsky  1 , Sheila Maria Barbosa de Lima  1 , Ana Paula Dinis Ano Bom  1 , Patrícia Cristina da Costa Neves  1 , Alcides Pissinatti  2   3 , Marcos da Silva Freire  1
Affiliations

Safety and immunogenicity of 17DD attenuated yellow fever vaccine in howler monkeys (Alouatta spp.)

André Tavares da Silva Fernandes et al. J Med Primatol. 2021 Feb.

Abstract

Background: Alouatta spp. are highly susceptible to yellow fever (YF) infection and develop an often fatal disease. The threat posed by an outbreak started in 2016 leads us to investigate vaccination as a potential tool in preventing YF in non-human primates (NHP).

Methods: Susceptible howler monkeys were immunized with three different concentrations of the human Brazilian commercial YF17DD vaccine. Post-vaccination viremia/RNAemia, immunogenicity, and safety were characterized.

Results: The vaccine did not produce YF clinical manifestations in any of the NHPs. After immunization, all animals seroconverted demonstrating the ability of the YF vaccine to induce humoral response in Alouatta species.

Conclusions: The present work has demonstrated the safe and immunogenic profile of the existing YF 17DD vaccine in howler monkeys. This knowledge may support further studies with other susceptible monkey species and provide a possible solution for controlling epizootics and preventing the devastation of endangered species.

Keywords: Alouatta; Atelidae; epizootic; howler monkey; monkey immunization; sentinel monkey; vaccine efficacy; virus; yellow fever.

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