Hydroxychloroquine pre-exposure prophylaxis for COVID-19 in healthcare workers

doi:10.1093/jac/dkaa477

. 2021 Feb 11;76(3):827-829.

doi: 10.1093/jac/dkaa477.

Hydroxychloroquine pre-exposure prophylaxis for COVID-19 in healthcare workers

Boris Revollo¹, Cristian Tebe², Judith Peñafiel², Ignacio Blanco³, Nuria Perez-Alvarez^{1

4}, Ruth Lopez⁵, Laura Rodriguez⁶, Josep Ferrer⁷, Pilar Ricart⁸, Enrique Moret⁹, Cristina Tural⁷, Anna Carreres¹⁰, Joan Matllo⁵, Sebastià Videla^{1

11}, Bonaventura Clotet^{1

12

13}, Josep M Llibre¹

Affiliations

¹ Division of Infectious Diseases and FLS Foundation for Fighting AIDS, Infectious Diseases and Promoting Health and Science, University Hospital Germans Trias, Badalona, Spain.
² Biostatistics Unit, Bellvitge Biomedical Research Institute (IDIBELL)/University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
³ Metropolitana Nord Laboratory, Institut Català de la Salut, Badalona, Spain.
⁴ Statistics and Operations Research Department, Universitat Politècnica de Catalunya-Barcelona Tech, Barcelona, Spain.
⁵ Occupational Risk Prevention Unit, University Hospital Germans Trias, Badalona, Spain.
⁶ Pulmonary Medicine, University Hospital Germans Trias, Badalona, Spain.
⁷ Internal Medicine Department, University Hospital Germans Trias, Badalona, Spain.
⁸ Intensive Care Unit Division, University Hospital Germans Trias, Badalona, Spain.
⁹ Anaesthesiology Department, University Hospital Germans Trias, Badalona, Spain.
¹⁰ Emergency Department, University Hospital Germans Trias, Badalona, Spain.
¹¹ Clinical Research Support Unit, Clinical Pharmacology Department, Bellvitge University Hospital/Bellvitge Biomedical Research Institute (IDIBELL)/University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
¹² Universitat de Vic-Universitat Central de Catalunya (UVIC-UCC), Vic, Spain.
¹³ Universitat Autònoma de Barcelona, Bellaterra, Spain.

PMID: 33219675
PMCID: PMC7717339
DOI: 10.1093/jac/dkaa477

Hydroxychloroquine pre-exposure prophylaxis for COVID-19 in healthcare workers

Boris Revollo et al. J Antimicrob Chemother. 2021.

. 2021 Feb 11;76(3):827-829.

doi: 10.1093/jac/dkaa477.

Authors

Affiliations

¹ Division of Infectious Diseases and FLS Foundation for Fighting AIDS, Infectious Diseases and Promoting Health and Science, University Hospital Germans Trias, Badalona, Spain.
² Biostatistics Unit, Bellvitge Biomedical Research Institute (IDIBELL)/University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
³ Metropolitana Nord Laboratory, Institut Català de la Salut, Badalona, Spain.
⁴ Statistics and Operations Research Department, Universitat Politècnica de Catalunya-Barcelona Tech, Barcelona, Spain.
⁵ Occupational Risk Prevention Unit, University Hospital Germans Trias, Badalona, Spain.
⁶ Pulmonary Medicine, University Hospital Germans Trias, Badalona, Spain.
⁷ Internal Medicine Department, University Hospital Germans Trias, Badalona, Spain.
⁸ Intensive Care Unit Division, University Hospital Germans Trias, Badalona, Spain.
⁹ Anaesthesiology Department, University Hospital Germans Trias, Badalona, Spain.
¹⁰ Emergency Department, University Hospital Germans Trias, Badalona, Spain.
¹¹ Clinical Research Support Unit, Clinical Pharmacology Department, Bellvitge University Hospital/Bellvitge Biomedical Research Institute (IDIBELL)/University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
¹² Universitat de Vic-Universitat Central de Catalunya (UVIC-UCC), Vic, Spain.
¹³ Universitat Autònoma de Barcelona, Bellaterra, Spain.

PMID: 33219675
PMCID: PMC7717339
DOI: 10.1093/jac/dkaa477

No abstract available

PubMed Disclaimer

Figures

**Figure 1.**
Compilation of ORs for COVID-19 infection in HCWs receiving hydroxychloroquine PrEP for COVID-19, assessed by either reverse real-time PCR (a) or by SARS-CoV-2 antibodies (b).

See this image and copyright information in PMC

Cited by

Prophylaxis for COVID-19: a systematic review.
Smit M, Marinosci A, Agoritsas T, Calmy A. Smit M, et al. Clin Microbiol Infect. 2021 Apr;27(4):532-537. doi: 10.1016/j.cmi.2021.01.013. Epub 2021 Jan 18. Clin Microbiol Infect. 2021. PMID: 33476807 Free PMC article.
Hospital-Based Quasi-Experimental Study on Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 in Healthcare Providers with Its Potential Side-Effects.
Shahrin L, Mahfuz M, Rahman MW, Hossain MR, Khandaker AM, Alam MA, Osmany DMMF, Islam MM, Chisti MJ, Ahmed CM, Ahmed T. Shahrin L, et al. Life (Basel). 2022 Dec 7;12(12):2047. doi: 10.3390/life12122047. Life (Basel). 2022. PMID: 36556412 Free PMC article.
Challenges and Opportunities from Targeting Inflammatory Responses to SARS-CoV-2 Infection: A Narrative Review.
Lariccia V, Magi S, Serfilippi T, Toujani M, Gratteri S, Amoroso S. Lariccia V, et al. J Clin Med. 2020 Dec 12;9(12):4021. doi: 10.3390/jcm9124021. J Clin Med. 2020. PMID: 33322733 Free PMC article. Review.
Safety of Short-Term Treatments with Oral Chloroquine and Hydroxychloroquine in Patients with and without COVID-19: A Systematic Review.
Marin S, Martin Val A, Bosch Peligero M, Rodríguez-Bernuz C, Pérez-Ricart A, Vilaró Jaques L, Paredes R, Roca J, Quiñones C. Marin S, et al. Pharmaceuticals (Basel). 2022 May 21;15(5):634. doi: 10.3390/ph15050634. Pharmaceuticals (Basel). 2022. PMID: 35631460 Free PMC article. Review.
HIV and COVID-19: Lessons From HIV and STI Harm Reduction Strategies.
Gravett RM, Marrazzo JM. Gravett RM, et al. Curr HIV/AIDS Rep. 2021 Aug;18(4):261-270. doi: 10.1007/s11904-021-00562-1. Epub 2021 Jun 8. Curr HIV/AIDS Rep. 2021. PMID: 34105091 Free PMC article. Review.

See all "Cited by" articles

References

1. CDC COVID-19 Response Team. Characteristics of health care personnel with COVID-19—United States, February 12–April 9, 2020. MMWR Morb Mortal Wkly Rep 2020; 69: 477–81. - PMC - PubMed
1. Garcia-Basteiro AL, Moncunill G, Tortajada M. et al. Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital. Nat Commun 2020; 11: 3500.. - PMC - PubMed
1. Morgan CJ. Reducing bias using propensity score matching. J Nucl Cardiol 2018; 25: 404–6. - PubMed
1. Rother N, Yanginlar C, Lindeboom RGH. et al. Hydroxychloroquine inhibits trained immunity - implications for COVID-19. medRxiv 2020; doi:10.1101/2020.06.08.20122143.
1. Guastalegname M, Vallone A. Could chloroquine/hydroxychloroquine be harmful in coronavirus disease 2019 (COVID-19) treatment? Clin Infect Dis 2020; 71: 888–9. - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

[1] CDC COVID-19 Response Team. Characteristics of health care personnel with COVID-19—United States, February 12–April 9, 2020. MMWR Morb Mortal Wkly Rep 2020; 69: 477–81. - PMC - PubMed

[2] CDC COVID-19 Response Team. Characteristics of health care personnel with COVID-19—United States, February 12–April 9, 2020. MMWR Morb Mortal Wkly Rep 2020; 69: 477–81. - PMC - PubMed

[3] Garcia-Basteiro AL, Moncunill G, Tortajada M. et al. Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital. Nat Commun 2020; 11: 3500.. - PMC - PubMed

[4] Garcia-Basteiro AL, Moncunill G, Tortajada M. et al. Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital. Nat Commun 2020; 11: 3500.. - PMC - PubMed

[5] Morgan CJ. Reducing bias using propensity score matching. J Nucl Cardiol 2018; 25: 404–6. - PubMed

[6] Morgan CJ. Reducing bias using propensity score matching. J Nucl Cardiol 2018; 25: 404–6. - PubMed

[7] Rother N, Yanginlar C, Lindeboom RGH. et al. Hydroxychloroquine inhibits trained immunity - implications for COVID-19. medRxiv 2020; doi:10.1101/2020.06.08.20122143.

[8] Rother N, Yanginlar C, Lindeboom RGH. et al. Hydroxychloroquine inhibits trained immunity - implications for COVID-19. medRxiv 2020; doi:10.1101/2020.06.08.20122143.

[9] Guastalegname M, Vallone A. Could chloroquine/hydroxychloroquine be harmful in coronavirus disease 2019 (COVID-19) treatment? Clin Infect Dis 2020; 71: 888–9. - PMC - PubMed

[10] Guastalegname M, Vallone A. Could chloroquine/hydroxychloroquine be harmful in coronavirus disease 2019 (COVID-19) treatment? Clin Infect Dis 2020; 71: 888–9. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Hydroxychloroquine pre-exposure prophylaxis for COVID-19 in healthcare workers

Affiliations

Hydroxychloroquine pre-exposure prophylaxis for COVID-19 in healthcare workers

Authors

Affiliations

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Medical