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Randomized Controlled Trial
. 2021 Jun;116(6):1569-1579.
doi: 10.1111/add.15349. Epub 2021 Jan 14.

The rewarding recovery study: a randomized controlled trial of incentives for alcohol and drug abstinence with a rural American Indian community

Michael G McDonell  1   2   3   4 , Jordan Skalisky  1   3 , Ekaterina Burduli  4   5 , Albert Foote Sr  2 , Alexandria Granbois  2 , Kenneth Smoker  2 , Katherine Hirchak  6 , Jalene Herron  6 , Richard K Ries  7 , Abigail Echo-Hawk  8 , Celestina Barbosa-Leiker  4   5 , Dedra Buchwald  2   3 , John Roll  1   3   4 , Sterling M McPherson  2   3   4
Affiliations
Randomized Controlled Trial

The rewarding recovery study: a randomized controlled trial of incentives for alcohol and drug abstinence with a rural American Indian community

Michael G McDonell et al. Addiction. 2021 Jun.

Abstract

Aims: To test if contingency management (CM) interventions for alcohol and drug abstinence were associated with increased alcohol and drug abstinence among American Indian adults with alcohol dependence who also use drugs.

Design: In this 2 × 2 factorial randomized controlled trial, American Indian adults with alcohol dependence who also used drugs were randomized to four conditions: (1) incentives for submission of urine samples only (control condition), (2) CM incentives for alcohol abstinence, (3) CM incentives for drug abstinence or (4) CM incentives for abstinence from both alcohol and drugs.

Setting: A Northern Plains Reservation in the United States.

Participants: A total of 114 American Indian adults aged 35.8 years (standard deviation = 10.4); 49.1% were male.

Intervention and comparator: Participants received incentives if they demonstrated abstinence from alcohol (CM for alcohol, n = 30), abstinence from their most frequently used drug (CM for drugs, n = 27) or abstinence from both alcohol and their most frequently used drug (CM for alcohol and drugs, n = 32) as assessed by urine tests. Controls (n = 25) received incentives for submitting urine samples only.

Measurements: Primary outcomes were urine ethyl glucuronide (alcohol) and drug tests conducted three times per week during the 12-week intervention period. Data analyses included listwise deletion and multiple imputation to account for missing data.

Findings: The three CM groups were significantly (P < 0.05) more likely to submit alcohol-abstinent urine samples compared with the control condition, with odds ratios ranging from 2.4 to 4.8. The CM for drugs (OR = 3.2) and CM for alcohol and drugs (OR = 2.5) were significantly more likely to submit urine samples that indicated drug abstinence, relative to the control condition (P < 0.05). However, these differences were not significant in multiple imputation analyses (P > 0.05).

Conclusions: Contingency management (CM) incentives for abstinence were associated with increased alcohol abstinence in American Indian adults diagnosed with alcohol dependence who also used drugs, living on a rural reservation. The effect of CM incentives on drug abstinence was inconclusive.

Trial registration: ClinicalTrials.gov NCT02222389.

Keywords: Alcohol; American Indians; contingency management; drug use; ethyl glucuronide; randomized clinical trial.

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Conflict of interest statement

Declarations of Interest

Drs. McPherson, Barbosa-Leiker, and Roll have received research funding from the Bristol-Myers Squibb Foundation. Dr. McPherson has also received research funding from Orthopedic Specialty Institute and consulted for Consistent Care company. Dr. Barbosa-Leiker has consulted for Providence Saint John’s Health Center. This funding is in no way related to the investigation reported here.

McDonell, Skalisky, Burduli, Foote, Granbois, Smoker, Echo-Hawk, Hirchak, Herron, Ries, and Buchwald have no financial relationships with commercial interests.

Figures

Figure 1.
Figure 1.
Overview of study procedures and CONSORT flow diagram.
Figure 2.
Figure 2.. Group differences in alcohol and most used drug abstinence assessed by urine tests.a
a The contingency management (CM) groups had significantly poorer attendance compared to the control group who received incentives for attendance only (p<.05). The two CM groups were significantly (p<.05) more likely to submit alcohol abstinent urine samples compared to the control condition (odds ratios ranging from 2.4 to 4.8). The CM for drug abstinence and CM for abstinence from both alcohol and drugs groups were significantly more likely than controls to submit urine samples consistent with abstinence from their most used drug (p<.05). Note: Timepoint 0 represents baseline. Weeks 1– 12 are intervention timepoints.
See this image and copyright information in PMC

References

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