Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb 8;39(2):125-129.
doi: 10.1016/j.ccell.2020.11.002. Epub 2020 Nov 20.

Normal Somatic Mutations in Cancer Transformation

Neshika Wijewardhane  1 , Lisa Dressler  2 , Francesca D Ciccarelli  3
Affiliations
Free article

Normal Somatic Mutations in Cancer Transformation

Neshika Wijewardhane et al. Cancer Cell. .
Free article

Abstract

Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understanding of tumorigenesis.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources