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Review
. 2021 Jun;22(2):225-239.
doi: 10.1007/s10561-020-09881-w. Epub 2020 Nov 22.

The useful agent to have an ideal biological scaffold

Raziyeh Kheirjou  1 , Jafar Soleimani Rad  2 , Ahad Ferdowsi Khosroshahi  1 , Leila Roshangar  3
Affiliations
Review

The useful agent to have an ideal biological scaffold

Raziyeh Kheirjou et al. Cell Tissue Bank. 2021 Jun.

Abstract

Tissue engineering which is applied in regenerative medicine has three basic components: cells, scaffolds and growth factors. This multidisciplinary field can regulate cell behaviors in different conditions using scaffolds and growth factors. Scaffolds perform this regulation with their structural, mechanical, functional and bioinductive properties and growth factors by attaching to and activating their receptors in cells. There are various types of biological extracellular matrix (ECM) and polymeric scaffolds in tissue engineering. Recently, many researchers have turned to using biological ECM rather than polymeric scaffolds because of its safety and growth factors. Therefore, selection the right scaffold with the best properties tailored to clinical use is an ideal way to regulate cell behaviors in order to repair or improve damaged tissue functions in regenerative medicine. In this review we first divided properties of biological scaffold into intrinsic and extrinsic elements and then explain the components of each element. Finally, the types of scaffold storage methods and their advantages and disadvantages are examined.

Keywords: Biological scaffold; Decellularization; Extracellular matrix; Storage; Tissue banking; Tissue engineering.

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