Surgery for Glioblastoma in Elderly Patients

Abstract

The management of glioblastoma in the elderly population represents a field of growing interest owing a longer life expectancy. In this age group, more than in the young adult, biological age is much more important than chronologic one. The date of birth should not exclude a priori access of treatments. Maximal safe resection is proved to be the first option when performance status and general health is good. Adjuvant therapy and decision about management of recurrence should be choose in a multidisciplinary group according to performance of the patients and O⁶-methylguanine-DNA methyl-transferase methylation.

Keywords: Adjuvant treatment; Chemotherapy; Elderly; Elderly patients; GBM; Radiotherapy; Resection; Survival.