Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jan;32(1):31-46.
doi: 10.1016/j.nec.2020.08.003. Epub 2020 Nov 5.

Advancing Imaging to Enhance Surgery: From Image to Information Guidance

Marco Riva  1 , Egesta Lopci  2 , Lorenzo G Gay  3 , Marco Conti Nibali  4 , Marco Rossi  3 , Tommaso Sciortino  3 , Antonella Castellano  5 , Lorenzo Bello  3
Affiliations
Free article
Review

Advancing Imaging to Enhance Surgery: From Image to Information Guidance

Marco Riva et al. Neurosurg Clin N Am. 2021 Jan.
Free article

Abstract

Conventional magnetic resonance imaging (cMRI) has an established role as a crucial disease parameter in the multidisciplinary management of glioblastoma, guiding diagnosis, treatment planning, assessment, and follow-up. Yet, cMRI cannot provide adequate information regarding tissue heterogeneity and the infiltrative extent beyond the contrast enhancement. Advanced magnetic resonance imaging and PET and newer analytical methods are transforming images into data (radiomics) and providing noninvasive biomarkers of molecular features (radiogenomics), conveying enhanced information for improving decision making in surgery. This review analyzes the shift from image guidance to information guidance that is relevant for the surgical treatment of glioblastoma.

Keywords: Glioblastoma; Image guidance; Magnetic resonance imaging (MRI); PET; Presurgical planning; Radiomics; Surgery.

PubMed Disclaimer

Conflict of interest statement

Disclosure The MRI protocol reported in Figs. 1 and 2 has been performed in the context of the Enhanced Delivery Ecosystem for Neurosurgery in 2020 (EDEN2020) project, which received funding from the European Union’s EU Research and Innovation programme Horizon 2020 under Grant Agreement no. 688279.