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. 2020 Nov 20;12(22):22399-22404.
doi: 10.18632/aging.104114. Epub 2020 Nov 20.

Impact of age on duration of viral RNA shedding in patients with COVID-19

Chenliang Zhou  1 , Tianfang Zhang  2 , Haotang Ren  2 , Shanshan Sun  2 , Xia Yu  2 , Jifang Sheng  2 , Yu Shi  2 , Hong Zhao  2
Affiliations

Impact of age on duration of viral RNA shedding in patients with COVID-19

Chenliang Zhou et al. Aging (Albany NY). .

Abstract

Background: The aim of this study was to investigate the host factors of patients with COVID-19 that were associated with delayed viral RNA clearance in specimens obtained from the upper respiratory tract.

Results: A median of a 32-day period of viral RNA shedding was observed, ranging from 4 days to 111 days. On multivariate analysis, elderly age was independently associated with prolonged viral shedding (OR = 1.02, 95% CI: 1.01-1.04, P = 0.003). An incremental increase in the duration of viral RNA shedding was observed with increasing age (P < 0.05). The median (quartile) duration of viral RNA shedding was 23 (22) days (≤ 40 years), 30 (18) days (41-50 years), 33 (21) days (51-60 years), 34 (17) days (61-70 years) and 34 (17) days (> 70 years).

Conclusions: Viral RNA shedding can persist for as long as 111 days in the upper respiratory tract. Increasing age is associated with viral RNA persistence.

Method: The demographic and virological data of patients with laboratory-confirmed COVID-19 were retrospectively analyzed. A multivariate logistic regression analysis was performed to identify significant risk factors associated with delayed viral RNA clearance. The duration of viral shedding was compared among age-stratified groups.

Keywords: COVID-19; SARS-CoV-2; risk factors; viral shedding.

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Conflict of interest statement

CONFLICTS OF INTEREST: The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Histograms of periods of viral RNA shedding (days) in patients with COVID-19 and different age groups.
See this image and copyright information in PMC

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