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. 2020 Nov 5:11:599918.
doi: 10.3389/fneur.2020.599918. eCollection 2020.

How to Design Optimal Accelerated rTMS Protocols Capable of Promoting Therapeutically Beneficial Metaplasticity

Alix C Thomson  1   2   3 , Alexander T Sack  1   2   3
Affiliations

How to Design Optimal Accelerated rTMS Protocols Capable of Promoting Therapeutically Beneficial Metaplasticity

Alix C Thomson et al. Front Neurol. .
No abstract available

Keywords: accelerated rTMS; hebbian plasticity; homeostatic plasticity; metaplasticity; transcrancial magnetic stimulation (TMS).

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Figures

Figure 1
Figure 1
Theoretical stimulation setup and effects in response to different spacings between repeated stimulations. (A) Repeating excitatory (iTBS) stimulation 3 times, with 60 min between sessions, promotes additive strengthening of stimulated synapses. Overall, the repeated stimulation increases potentiation [this has been shown in animals using a different TBS protocol (43, 45)]. (B) Repeating the same 3 iTBS stimulations, but with only 10 min between sessions results in stabilization (homeostatic metaplasticity) and no change in overall plasticity.
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