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Review
. 2020 Nov 5:11:575258.
doi: 10.3389/fimmu.2020.575258. eCollection 2020.

FGFR3 Alterations in the Era of Immunotherapy for Urothelial Bladder Cancer

Alec Kacew  1 , Randy F Sweis  1   2   3
Affiliations
Review

FGFR3 Alterations in the Era of Immunotherapy for Urothelial Bladder Cancer

Alec Kacew et al. Front Immunol. .

Abstract

FGFR3 is a prognostic and predictive marker and is a validated therapeutic target in urothelial bladder cancer. Its utility as a marker and target in the context of immunotherapy is incompletely understood. We review the role of FGFR3 in bladder cancer and discuss preclinical and clinical clues of its effectiveness as a patient selection factor and therapeutic target in the era of immunotherapy.

Keywords: bladder cancer; fibroblast growth factor receptor; immunotherapy; pharmacogenetics; targeted molecular therapy.

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Figures

Figure 1
Figure 1
(A) FGFR3 gene alterations by cancer type based on available data from The Cancer Genome Atlas (TCGA) (only recurrent mutations and fusions—those comprising in >1% of mutations/fusions—were included). Potential mechanisms of improved response rate to FGFR3-targeted therapy in the post-immunotherapy setting include (B) primary immunotherapy resistance, (C) secondary immunotherapy resistance, and (D) enrichment of patients with immunotherapy-resistant tumors in trials of FGFR3-targeted therapy.
See this image and copyright information in PMC

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