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. 1987 Dec 1;435(1-2):371-6.
doi: 10.1016/0006-8993(87)91628-3.

Unique behavioral effects of the NMDA antagonist, CPP, upon injection into the medial pre-frontal cortex of rats

K A O'Neill  1 , J M Liebman
Affiliations

Unique behavioral effects of the NMDA antagonist, CPP, upon injection into the medial pre-frontal cortex of rats

K A O'Neill et al. Brain Res. .

Abstract

Injection of the specific N-methyl-D-aspartate (NMDA) antagonist, 3(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), into the frontal cortex of rats, induced hyperactivity characterized by unique episodic darting behavior. This behavioral profile contrasts sharply with the ataxia and hyperactivity seen after intracerebroventricular CPP and other NMDA antagonists.

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