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Review
. 2020 Nov 23;11(1):491.
doi: 10.1186/s13287-020-01994-z.

Application of adipose-derived stem cells in photoaging: basic science and literature review

Shidie Chen  1 , Zhigang He  2 , Jinghong Xu  3
Affiliations
Review

Application of adipose-derived stem cells in photoaging: basic science and literature review

Shidie Chen et al. Stem Cell Res Ther. .

Abstract

Photoaging is mainly induced by continuous exposure to sun light, causing multiple unwanted skin characters and accelerating skin aging. Adipose-derived stem cells(ADSCs) are promising in supporting skin repair because of their significant antioxidant capacity and strong proliferation, differentiation, and migration ability, as well as their enriched secretome containing various growth factors and cytokines. The identification of the mechanisms by which ADSCs perform these functions for photoaging has great potential to explore therapeutic applications and combat skin aging. We also review the basic mechanisms of UV-induced skin aging and recent improvement in pre-clinical applications of ADSCs associated with photoaging. Results showed that ADSCs are potential to address photoaging problem and might treat skin cancer. Compared with ADSCs alone, the secretome-based approaches and different preconditionings of ADSCs are more promising to overcome the current limitations and enhance the anti-photoaging capacity.

Keywords: Adipose-derived stem cell; Aging; Conditioned medium; Exosome; Photoaging; Reactive oxygen species; Secretome; Skin aging.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
UV-induced skin aging model
Fig. 2
Fig. 2
Schematic representation of the effects of ADSCs on photoaging
See this image and copyright information in PMC

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