Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jan;17(1):112-114.
doi: 10.1002/alz.12234. Epub 2020 Nov 23.

Alzheimer's team care approach-akin to diabetes-in the development, validation, and population assessment of retinal biomarkers for disease

Michael R Dueñas  1 , Peter J Snyder  2
Affiliations

Alzheimer's team care approach-akin to diabetes-in the development, validation, and population assessment of retinal biomarkers for disease

Michael R Dueñas et al. Alzheimers Dement. 2021 Jan.

Abstract

There exists a public health imperative to discover and to develop disease-modifying Alzheimer's disease (AD) therapeutics to protect the health of millions of individuals facing AD. Achievement of this goal will be dependent on developing the clinical tools to detect high risk, in the earliest phases of the disease, and at the population level. This article describes the study of retinal biomarkers for the identification of, and tracking of change over time for, individuals in the preclinical stage of AD and substantiates the need for a major cross-disciplinary effort for comparison across labs and clinical sites using diabetes risk monitoring as a perfect analogy. Proposed framework would: (1) support AD working groups across disciplines; (2) establish common imaging platforms to develop and test basic standards, and minimum datasets to embrace and test novel innovations as they emerge; and (3) accelerate AD prevention and quality improvement in real-world care.

Keywords: Alzheimer's; biomarkers; diagnostic screening; early detection; optical coherence tomography; retinal.

PubMed Disclaimer

References

REFERENCES

    1. Alber J, Goldfarb D, Thompson LI, et al. Developing retinal biomarkers for the earliest stages of Alzheimer's disease: What we know, what we don't, and how to move forward. Alzheimers Dement. 2020;16(1):229-243.
    1. Rojas M, Zhang W, Xu Z, et al. Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury. PLoS ONE, 2013;8(12):e84357.
    1. The Prevention and Treatment of Complications of Diabetes Mellitus A Guide for Primary Care Practitioners Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Center for Chronic Disease Prevention and Health Promotion, Division of Diabetes Translation Publication date: 01/01/1991 https://wonder.cdc.gov/wonder/prevguid/p0000063/p0000063.asp
    1. American Diabetes Association: clinical practice recommendations 1995. Diabetes Care. 1995;18(suppl 1):1-96.
    1. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539-553.

LinkOut - more resources