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Editorial
. 2021 Mar 15;203(6):667-669.
doi: 10.1164/rccm.202010-3898ED.

Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis?

Vincent C Auyeung  1 , Dean Sheppard  1
Affiliations
Editorial

Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis?

Vincent C Auyeung et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Model for Sin3a loss of function–induced fibrosis and outstanding questions. IPF = idiopathic pulmonary fibrosis; LOF = loss of function; SASP = senescence-associated secretory phenotype.
See this image and copyright information in PMC

Comment on

  • Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis.
    Yao C, Guan X, Carraro G, Parimon T, Liu X, Huang G, Mulay A, Soukiasian HJ, David G, Weigt SS, Belperio JA, Chen P, Jiang D, Noble PW, Stripp BR. Yao C, et al. Am J Respir Crit Care Med. 2021 Mar 15;203(6):707-717. doi: 10.1164/rccm.202004-1274OC. Am J Respir Crit Care Med. 2021. PMID: 32991815 Free PMC article.

References

    1. Yao C, Guan X, Carraro G, Parimon T, Liu X, Huang G, et al. Senescence of alveolar type 2 cells drives progressive pulmonary fibrosis. Am J Respir Crit Care Med. 2021;203:707–717. - PMC - PubMed
    1. Kathiriya JJ, Brumwell AN, Jackson JR, Tang X, Chapman HA. Distinct airway epithelial stem cells hide among club cells but mobilize to promote alveolar regeneration. Cell Stem Cell. 2020;26:346–358, e4. - PMC - PubMed
    1. Strunz M, Simon LM, Ansari M, Kathiriya JJ, Angelidis I, Mayr CH, et al. Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis. Nat Commun. 2020;11:3559. - PMC - PubMed
    1. Kobayashi Y, Tata A, Konkimalla A, Katsura H, Lee RF, Ou J, et al. Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis. Nat Cell Biol. 2020;22:934–946. - PMC - PubMed
    1. Jiang P, Gil de Rubio R, Hrycaj SM, Gurczynski SJ, Riemondy KA, Moore BB, et al. Ineffectual type 2-to-type 1 alveolar epithelial cell differentiation in idiopathic pulmonary fibrosis: persistence of the KRT8hi transitional state. Am J Respir Crit Care Med. 2020;201:1443–1447. - PMC - PubMed

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