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Review
. 2021 Jan 1:209:112885.
doi: 10.1016/j.ejmech.2020.112885. Epub 2020 Sep 28.

Application of sulfoximines in medicinal chemistry from 2013 to 2020

Yu Han  1 , Kun Xing  1 , Jian Zhang  1 , Tong Tong  1 , Yuntao Shi  1 , Hongxue Cao  1 , Huan Yu  1 , Yu Zhang  1 , Dan Liu  2 , Linxiang Zhao  3
Affiliations
Review

Application of sulfoximines in medicinal chemistry from 2013 to 2020

Yu Han et al. Eur J Med Chem. .

Abstract

In recent years, interest in sulfoximine chemistry has been greatly increased. For example, at least three sulfoximine containing drugs BAY 1143572, BAY 1251152 and AZD6738 have entered the clinic. Despite the increasing interest in sulfoximines and their chemistry, the routine application of this structure in drug discovery is still hampered due to limited experience in physicochemical and in vitro parameters of sulfoximines. Therefore, we reviewed all relevant articles from 2013 to the present in terms of potency and pharmacokinetic properties in order to support the addition of the sulfoximine component to the toolbox of medicinal chemists.

Keywords: Drug design; Pharmacophore; Sulfoximine.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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