Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr;51(3):546-557.
doi: 10.1080/08820139.2020.1851709. Epub 2020 Nov 23.

Association of TNF-α G-308 a Promoter Polymorphism with the Course and Outcome of COVID-19 Patients

Ahmed Saleh  1 , Ahmed Sultan  1 , Mohamed A Elashry  1 , Ahmed Farag  1 , Metwaly Ibrahim Mortada  2 , Mayada A Ghannam  2 , Ahmed M Saed  1 , Elsayed Ghoneem  1
Affiliations

Association of TNF-α G-308 a Promoter Polymorphism with the Course and Outcome of COVID-19 Patients

Ahmed Saleh et al. Immunol Invest. 2022 Apr.

Abstract

Background: Tumor necrosis factor-ɑ (TNF-ɑ) is one of the most important cytokines that manage the host defense mechanism, which may play a role in the pathogenesis of COVID-19 patients. The work aims to study the association of TNF-ɑ G-308 A gene polymorphism with the course and outcome of COVID-19 patients in Mansoura University Hospital.

Methods: 900 patients with COVID-19 infection and 184 controls were tested for TNF-ɑ G-308 A promoter polymorphism. Different genotypes of TNF-ɑ G-308 A were compared as regards the severity and prognosis of the disease.

Results: No statistically significant difference was found between patients and controls as regards the demographic data. The AA genotype of TNF-ɑ showed a higher incidence of the disease in comparison to the other genotypes. As regards the demographic and laboratory characters, no statistically significant difference was found between the different genotypes except for age, lymphopenia, CRP, and serum ferritin levels. In 336(80.0%) cases of the AA genotype, the disease was severe in comparison to 90(41.7%) cases in the GA genotype and no cases in the GG genotype with P = .001.

Conclusion: People who carry the A allele of TNF-ɑ polymorphism are more prone to COVID-19 infection. The AA genotype of TNF-ɑ is associated with a more aggressive pattern of the disease. In those patients, the use of anti - TNF therapy may be promising.

Keywords: COVID-19; Polymorphism; Tumor necrosis factor.

PubMed Disclaimer

References

    1. Bidwell J, Keen L, Gallagher G, Kimberly R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C, et al. 1999. Cytokine gene polymorphism in human disease: on-line databases. Genes Immun. 1:3–19. - PubMed
    1. Brenner EJ, Ungaro RC, Gearry RB, Kaplan GG, Kissous-Hunt M, Lewis JD, Ng SC, Rahier J-F, Reinisch W, Ruemmele FM, et al. 2020. Corticosteroids, but not TNF antagonists, are associated with adverse COVID-19 outcomes in patients with inflammatory bowel diseases: results from an international registry. Gastroenterol. 159(91.e3):481. - PMC - PubMed
    1. Crayne CB, Albeituni S, Nichols KE, Cron RQ. 2019. The immunology of macrophage activation syndrome. Front Immunol. 10:119. doi:10.3389/fimmu.2019.00119. e Collection 2019. - DOI - PMC - PubMed
    1. Dinarello CA. 2000. Proinflammatory cytokines. Chest. 118:503–58. - PubMed
    1. Ding Y, He L, Zhang Q, Huang Z, Che X, Hou J, Wang H, Shen H, Qiu L, Li Z, et al. 2004. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways. J Pathol. 203:622–30. - PMC - PubMed

Substances