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Meta-Analysis
. 2020 Nov 23;20(1):1134.
doi: 10.1186/s12885-020-07606-6.

Association between five types of Tumor Necrosis Factor-α gene polymorphism and hepatocellular carcinoma risk: a meta-analysis

Citrawati Dyah Kencono Wungu  1   2 , Fis Citra Ariyanto  3   4 , Gwenny Ichsan Prabowo  5 , Soetjipto  5   6 , Retno Handajani  5   6
Affiliations
Meta-Analysis

Association between five types of Tumor Necrosis Factor-α gene polymorphism and hepatocellular carcinoma risk: a meta-analysis

Citrawati Dyah Kencono Wungu et al. BMC Cancer. .

Abstract

Background: Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysis to determine the association between TNF-α promoter SNPs: -1031 T/C, - 863 C/A, - 857 C/T, - 308 G/A, and - 238 G/A with HCC risk.

Methods: We interrogated articles from journal database: PubMed, Pro-Quest, EBSCO, Science Direct, and Springer to determine the relationship between five types of SNPs in TNF-α gene with HCC risk. RevMan 5.3 software was used for analysis in fixed/random effect models.

Results: This meta-analysis included 23 potential articles from 2004 to 2018 with 3237 HCC cases and 4843 controls. We found that SNP - 863 C/A were associated with a significantly increased HCC risk (A vs C, OR = 1.31, 95% CI = 1.03-1.67). Similar results were obtained in - 857 C/T (TT/CT vs CC, OR = 1.31, 95% CI = 1.06-1.62), - 308 G/A (AA vs GG, OR = 3.14, 95% CI = 2.06-4.79), and - 238 G/A (AA vs GG, OR = 3.87, 95% CI = 1.32-11.34). While no associations were observed between SNP TNF-α - 1031 T/C and HCC risk.

Conclusions: The present meta-analysis showed that TNFα SNPs -863C/A, - 857 C/T, - 308 G/A, and - 238 G/A were associated with the risk of HCC.

Keywords: Hepatocellular carcinoma; Meta-analysis; Single nucleotide polymorphism; Tumor necrosis factor-α.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
PRISMA diagram of the literature search
Fig. 2
Fig. 2
Allele model (A vs C) of SNP TNF-α 863C/A on HCC risk. The association was indicated as odds ratio (OR) estimate with 95% CI. Odd Ratio > 1 shows the increased risk of HCC
Fig. 3
Fig. 3
Dominant-model analysis (TT/CT vs CC) of SNP TNF-α 857 C/T on HCC risk
Fig. 4
Fig. 4
(a) Allele model analysis (A vs G), (b) Dominant model analysis (AA+GA vs GG), (c) Codominant major vs minor homozygote-model analysis (AA vs GG), (d) Recessive-model analysis (AA vs GA+GG), and (e) codominant heterozygote vs major homozygote model analysis (GA vs GG) of SNP TNF-α 238 G/A on HCC risk.
Fig. 5
Fig. 5
Codominant-model analysis (AA vs GG) of SNP TNF-α 238 G/A on HCC risk
See this image and copyright information in PMC

References

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