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Case Reports
. 2021 Jan 14;83(1):108-111.
doi: 10.1292/jvms.20-0403. Epub 2020 Nov 24.

Disseminated histiocytic sarcoma in Asian palm civet (Paradoxurus hermaphroditus)

Kittikorn Boonsri  1 , Sakorn Dechkajorn  2 , Kornravee Photichai  1 , Saralee Srivorakul  1 , Hassadin Boonsriroj  3 , Atigan Thongtharb  4   5 , Kidsadagon Pringproa  1   6
Affiliations
Case Reports

Disseminated histiocytic sarcoma in Asian palm civet (Paradoxurus hermaphroditus)

Kittikorn Boonsri et al. J Vet Med Sci. .

Abstract

This case study had focused on a male, 7-year-old Asian palm civet (Paradoxurus hermaphroditus) with a history of biting its tail and the development of skin masses around its inguinal area, prior to its death. Macroscopically, multiple firm white nodular masses of 0.5-5 cm in diameter were found in the subcutis of the inguinal area, and in the lungs, spleen and liver. Microscopically, masses in the skin, lungs and spleen were composed of neoplastic spindle cells admixed with mononuclear cells and multinucleated giant cells. The neoplastic cells were arranged in a sheet pattern. Immunohistochemically, the neoplastic cells were immunohistochemically positive for vimentin, Iba-1, CD 204 and Human leukocyte antigen (HLA)-DR, while the cells were negative for cytokeratin and smooth muscle actin. Based on the histopathological and immunohistochemical results, disseminated histiocytic sarcoma was diagnosed.

Keywords: civet; disseminated histiocytic sarcoma.

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Conflict of interest statement

The author(s) declared no conflicts of interest with respect to the authorship and/or publication of this article.

Figures

Fig. 1.
Fig. 1.
Gross findings of tumor in a male 7-year-old Asian palm civet (Paradoxurus hermaphroditus) with disseminated histiocytic sarcoma. Skin masses at the inguinal area (A). Multifocal nodular masses (arrows) in the lungs (B). White foci (arrows) in the liver (C). Nodular masses (arrows) in the spleen (D). Bars=1 cm.
Fig. 2.
Fig. 2.
Histological findings of disseminated histiocytic sarcoma in a male 7-year-old Asian palm civet (Paradoxurus hermaphroditus); subcutaneous mass. Neoplastic spindle cells are notably oval and bizarre with hyperchromatic nuclei containing prominent nucleoli and abundant eosinophilic cytoplasm. Many multinucleated giant neoplastic cells are also observed (arrows). Hematoxylin and eosin. Bar=20 µm.
Fig. 3.
Fig. 3.
Immunohistopathological findings of disseminated histiocytic sarcoma in a male, 7-year-old Asian palm civet (Paradoxurus hermaphroditus). Neoplastic cells in the subcutaneous mass are positive for vimentin (A), major histocompatibility complex (MHC) class II (B), CD204 (C) and Iba1 (D). Bars=50 µm.
See this image and copyright information in PMC

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