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. 2020 Nov 23;10(1):20347.
doi: 10.1038/s41598-020-77317-2.

Applicability of minimally invasive surgery for clinically T4 colorectal cancer

Yu-Tso Liao  1   2 , Jin-Tung Liang  3
Affiliations

Applicability of minimally invasive surgery for clinically T4 colorectal cancer

Yu-Tso Liao et al. Sci Rep. .

Abstract

The role of minimally invasive surgery (MIS) to treat clinically T4 (cT4) colorectal cancer (CRC) remains uncertain and deserves further investigation. A retrospective cohort study was conducted between September 2006 and March 2019 recruiting patients diagnosed as cT4 CRC and undergoing MIS at a university hospital and its branch. Patients' demography, clinicopathology, surgical and oncological outcomes, and radicality were analyzed. A total of 128 patients were recruited with an average follow-up period of 33.8 months. The median time to soft diet was 6 days, and the median postoperative hospitalization periods was 11 days. The conversion and complication (Clavien-Dindo classification ≥ II) rates were 7.8% and 27.3%, respectively. The 30-day mortality was 0.78%. R0 resection rate was 92.2% for cT4M0 and 88.6% for pT4M0 patients. For cT4 CRC patients, the disease-free survival and 3-year overall survival were 86.1% and 86.8% for stage II, 54.1% and 57.9% for stage III, and 10.8% and 17.8% for stage IV. With acceptable conversion, complication and mortality rate, MIS may achieve satisfactory R0 resection rate and thus lead to good oncological outcomes for selected patients with cT4 CRC.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Patients’ recruitment and selection for clinically T4 lesion of colorectal cancer.
Figure 2
Figure 2
(a) Overall survival according to the tumor-node-metastasis (TNM) stages. (b) Disease-free survival according to the tumor-node-metastasis (TNM) stages.
Figure 3
Figure 3
(a) Overall survival according to the radicality. (b) Disease-free survival according to the radicality.
See this image and copyright information in PMC

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