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Comment
. 2021 May;87(5):2401-2402.
doi: 10.1111/bcp.14633. Epub 2020 Nov 23.

End-point selection to determine the airway-systemic ratio of inhaled corticosteroids in asthma

Brian Lipworth  1 , Rory Chan  1 , Chris Rui Wen Kuo  1
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Comment

End-point selection to determine the airway-systemic ratio of inhaled corticosteroids in asthma

Brian Lipworth et al. Br J Clin Pharmacol. 2021 May.
Free article

Abstract

The use of adenosine monophosphate challenge and basal cortisol as short-term surrogate end points of airway-systemic effects of inhaled corticosteroids in asthma is not suitable to properly determine the clinically relevant long-term therapeutic index.

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