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Review
. 2020 Dec;118(6):e514-e526.
doi: 10.5546/aap.2020.eng.e514.

Recommendations for the initial management of multisystem inflammatory syndrome temporally related to COVID-19, in children and adolescents

[Article in English, Spanish]
Guillermo Kohn-Loncarica  1 , Ana Fustiñana  2 , Franco Díaz-Rubio  3 , Juan C Jaramillo-Bustamante  4 , Sebastián González-Dambrauskas  5 , Pablo Vásquez-Hoyos  6 , Jaime Fernández-Sarmiento  7 , Gustavo González  8 , Alejandro Mansur  9 , Javier Ponce  10 , Roberto Jabornisky  11
Affiliations
Free article
Review

Recommendations for the initial management of multisystem inflammatory syndrome temporally related to COVID-19, in children and adolescents

[Article in English, Spanish]
Guillermo Kohn-Loncarica et al. Arch Argent Pediatr. 2020 Dec.
Free article

Abstract
in English, Spanish

Multisystem inflammatory syndrome temporally related to COVID-19 in children and adolescents is a clinical presentation of SARS-CoV-2 infection. It shares some features with Kawasaki disease, toxic shock, sepsis, macrophage activation syndrome, and myocarditis. Few publications have addressed its initial management, which is similar to that proposed for septic shock. This review analyzes such approach based on the characteristics typical of multisystem inflammatory syndrome related to COVID-19 in accordance with the paradigm of an "institutional practice guideline" and suggests therapeutic approach strategies, including early detection, stabilization, referral, specific treatment, and process analysis.

El síndrome inflamatorio multisistémico en niños y adolescentes temporalmente relacionado con COVID-19 es una presentación clínica de la infección por SARS-CoV-2. Comparte algunas características con la enfermedad de Kawasaki, el shock tóxico, la sepsis, el síndrome de activación macrofágica y la miocarditis. Son escasas las publicaciones que abordan su manejo inicial, que tiene semejanzas con el propuesto para el shock séptico. Esta revisión analiza dicho abordaje basado en las características propias del síndrome inflamatorio multisistémico relacionado con COVID-19, de acuerdo con el paradigma de construcción de una “guía de práctica institucional”, y sugiere estrategias de aproximación terapéutica, que incluyen detección temprana, estabilización, referencia, tratamiento específico y análisis de procesos.

Keywords: COVID-19; SARSCoV-2; multisystem inflammatory syndrome; patient care bundles; sepsis.

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Conflict of interest statement

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References

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