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. 2021 Mar 1;273(3):449-458.
doi: 10.1097/SLA.0000000000004365.

Breast Implant-associated Anaplastic Large Cell Lymphoma: An Evidence-based Systematic Review

Ryan C DeCoster  1   2 , Evan B Lynch  2 , Alisha R Bonaroti  2 , John Matthew Webster  3 , Timothy A Butterfield  4 , Bernard Mark Evers  1 , Henry C Vasconez  2 , Mark W Clemens  5
Affiliations

Breast Implant-associated Anaplastic Large Cell Lymphoma: An Evidence-based Systematic Review

Ryan C DeCoster et al. Ann Surg. .

Abstract

Objective: This evidence-based systematic review synthesizes and critically appraises current clinical recommendations and advances in the diagnosis and treatment of BIA-ALCL. This review also aims to broaden physician awareness across diverse specialties, particularly among general practitioners, breast surgeons, surgical oncologists, and other clinicians who may encounter patients with breast implants in their practice.

Background: BIA-ALCL is an emerging and treatable immune cell cancer definitively linked to textured-surface breast implants. Although the National Comprehensive Cancer Network (NCCN) consensus guidelines and other clinical recommendations have been established, the evidence supporting these guidelines has not been systematically studied. The purpose of this evidence-based systematic review is to synthesize and critically appraise current clinical guidelines and recommendations while highlighting advances in diagnosis and treatment and raising awareness for this emerging disease.

Methods: This evidence-based systematic review evaluated primary research studies focusing on the diagnosis and treatment of BIA-ALCL that were published in PubMed, Google Scholar, and other scientific databases through March 2020.

Results and conclusions: The clinical knowledge of BIA-ALCL has evolved rapidly over the last several years with major advances in diagnosis and treatment, including en bloc resection as the standard of care. Despite a limited number of high-quality clinical studies comprised mainly of Level III and Level V evidence, current evidence aligns with established NCCN consensus guidelines. When diagnosed and treated in accordance with NCCN guidelines, BIA-ALCL carries an excellent prognosis.

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Conflict of interest statement

The authors report no conflicts of interest.

References

    1. Brody GS, Deapen D, Taylor CR, et al. Anaplastic large cell lymphoma occurring in women with breast implants: Analysis of 173 cases. Plast Reconstr Surg 2015; 135:695–705.
    1. Keech JA, Creech BJ. Anaplastic T-cell lymphoma in proximity to a saline-filled breast implant. Plast Reconstr Surg 1997; 100:554–555.
    1. Miranda RN, Medeiros LJ, Ferrufino-Schmidt MC, et al. Pioneers of breast implant-associated anaplastic large cell lymphoma: history from case report to global recognition. Plast Reconstr Surg 2019; 143 (3S A review of breast implant-associated anaplastic large cell lymphoma):7S–14S.
    1. Lyapichev KA, Medeiros LJ, Clemens MW, et al. Reconsideration of the first recognition of breast implant-associated anaplastic large cell lymphoma: a critical review of the literature. Ann Diagn Pathol 2020; 45:151474.
    1. Said JW, Tasaka T, Takeuchi S, et al. Primary effusion lymphoma in women: report of two cases of Kaposi's sarcoma herpes virus-associated effusion-based lymphoma in human immunodeficiency virus-negative women. Blood 1996; 88:3124–3128.

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