Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Nov 25;99(48):e23318.
doi: 10.1097/MD.0000000000023318.

Topical use of Jiawei Simiao Yongan Gao to prevent radiodermatitis in patients with head and neck cancer: A retrospective cohort study

Fengli Song  1 , Ziling Liao  2 , Tong Li  1 , Ning Kang  1 , Zhiming Li  2 , Shufang Fan  3 , Fengzhi Liu  2
Affiliations

Topical use of Jiawei Simiao Yongan Gao to prevent radiodermatitis in patients with head and neck cancer: A retrospective cohort study

Fengli Song et al. Medicine (Baltimore). .

Abstract

Radiodermatitis is a common side effect of radiotherapy, but currently there is no standard treatment for its prevention. This study aimed to observe the effect of topical application of a paste based on traditional Chinese medicine, Jiawei Simiao Yongan Gao, on radiodermatitis caused by radiotherapy for patients with head and neck cancer.This was a retrospective cohort study of 40 patients with head and neck cancer evaluated during their radiotherapy. Of these, 20 patients were treated with Jiawei Simiao Yongan Gao on the irradiated skin from the beginning of radiotherapy (JSY group). The other 20 patients were given standard nursing (standard group). Acute skin reactions were classified according to the radiation-induced skin reaction assessment scale (RISRAS) and American radiation therapy oncology group (RTOG) acute toxicity grading criteria every 2 weeks, and adverse effects were recorded until the end of the radiotherapy.The two groups showed differences in severity of radiodermatitis. At 0 to 30 Gy, the skin reactions were similar in the two groups, while above 40 Gy the skin reactions were significantly lower grade in the JSY group (P < .05). At 0 to 20 Gy, there was no statistical significance (P > .05); but above 30 Gy they were lower in the JSY group (P < .05).Jiawei Simiao Yongan Gao effectively alleviated acute radiodermatitis caused by radiotherapy of head and neck cancer patients compared with standard nursing.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Graph representing the proportion of dermatitis as monitored by the radiation therapy oncology group (RTOG) acute radiation toxicity scoring system. T on the x-axis represents the time after radiotherapy started. The y-axis represents the percentage of cases.
Figure 2
Figure 2
Graph showing the sum of the radiation-induced skin reaction assessment scale (RISRAS) scores. The time after the start of radiotherapy is shown as T on the x-axis, the y-axis shows the sum of RISRAS scores.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Häfner MF, Fetzner L, Hassel JC, et al. Prophylaxis of acute radiation dermatitis with an innovative FDA-approved two-step skin care system in a patient with head and neck cancer undergoing a platin-based radiochemotherapy: a case report and review of the literature. Dermatology 2013;227:171–4. - PubMed
    1. Cabezón-Gutiérrez L, Khosravi-Shahi P, Escobar-Álvarez Y. Management of dermatitis in patients with locally advanced squamous cell carcinoma of the head and neck receiving cetuximab and radiotherapy. Oral Oncol 2012;48:293–7. - PubMed
    1. Iacovelli NA, Galaverni M, Cavallo A, et al. Prevention and treatment of radiation-induced acute dermatitis in head and neck cancer patients: a systematic review. Future Oncol 2018;14:291–305. - PubMed
    1. Hegedus F, Mathew LM, Schwartz RA. Radiation dermatitis: an overview. Int J Dermatol 2017;56:909–14. - PubMed
    1. Franco P, Potenza I, Moretto F, et al. Hypericum perforatum and neem oil for the management of acute skin toxicity in head and neck cancer patients undergoing radiation or chemo-radiation: a single-arm prospective observational study. Radiat Oncol 2014;9:297. - PMC - PubMed

MeSH terms