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Comment
. 2020 Nov 24;5(1):277.
doi: 10.1038/s41392-020-00403-4.

ecDNA within tumors: a new mechanism that drives tumor heterogeneity and drug resistance

Xixi Zeng  1 , Maoping Wan  1 , Jianmin Wu  2
Affiliations
Comment

ecDNA within tumors: a new mechanism that drives tumor heterogeneity and drug resistance

Xixi Zeng et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Schematic summary of roles of amplified ecDNAs in cancer. EcDNA-based oncogene amplification promotes intratumoral genetic heterogeneity and is associated with aggressive cancer behavior, including tumor growth, metastasis, and drug resistance, resulting in poor outcomes for patients across multiple cancers
See this image and copyright information in PMC

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References

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