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Review
. 2021 Mar;22(3):154-168.
doi: 10.1038/s41576-020-00303-x. Epub 2020 Nov 24.

The relationship between genome structure and function

A Marieke Oudelaar  1 , Douglas R Higgs  2
Affiliations
Review

The relationship between genome structure and function

A Marieke Oudelaar et al. Nat Rev Genet. 2021 Mar.

Erratum in

Abstract

Precise patterns of gene expression in metazoans are controlled by three classes of regulatory elements: promoters, enhancers and boundary elements. During differentiation and development, these elements form specific interactions in dynamic higher-order chromatin structures. However, the relationship between genome structure and its function in gene regulation is not completely understood. Here we review recent progress in this field and discuss whether genome structure plays an instructive role in regulating gene expression or is a reflection of the activity of the regulatory elements of the genome.

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