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Comment
. 2021 Jan;22(1):1.
doi: 10.1038/s41576-020-00310-y.

Host genetics of coronavirus infection

Darren J Burgess  1
Affiliations
Comment

Host genetics of coronavirus infection

Darren J Burgess. Nat Rev Genet. 2021 Jan.

Abstract

Two new reports in Cell use genome-wide CRISPR screens to uncover host determinants of coronavirus infection, identifying potential leads for antiviral therapeutics.

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Comment on

  • Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.
    Wei J, Alfajaro MM, DeWeirdt PC, Hanna RE, Lu-Culligan WJ, Cai WL, Strine MS, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Ravindra NG, Gasque V, de Miguel FJ, Patil A, Chen H, Oguntuyo KY, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach BD, Politi K, van Dijk D, Kadoch C, Simon MD, Yan Q, Doench JG, Wilen CB. Wei J, et al. Cell. 2021 Jan 7;184(1):76-91.e13. doi: 10.1016/j.cell.2020.10.028. Epub 2020 Oct 20. Cell. 2021. PMID: 33147444 Free PMC article.
  • Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells.
    Daniloski Z, Jordan TX, Wessels HH, Hoagland DA, Kasela S, Legut M, Maniatis S, Mimitou EP, Lu L, Geller E, Danziger O, Rosenberg BR, Phatnani H, Smibert P, Lappalainen T, tenOever BR, Sanjana NE. Daniloski Z, et al. Cell. 2021 Jan 7;184(1):92-105.e16. doi: 10.1016/j.cell.2020.10.030. Epub 2020 Oct 24. Cell. 2021. PMID: 33147445 Free PMC article.

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References

    1. Daniloski Z, et al. Identification of required host factors for SARS-CoV-2 infection in human cells. Cell. 2020 doi: 10.1016/j.cell.2020.10.030. - DOI - PMC - PubMed
    1. Wei J, et al. Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection. Cell. 2020 doi: 10.1016/j.cell.2020.10.028. - DOI - PMC - PubMed

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