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. 2020 Nov-Dec;36(7):1688-1692.
doi: 10.12669/pjms.36.7.2018.

Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma

Xiaoxia Dai  1 , Tao Feng  2 , Xuejuan Zhang  3 , Kaishu Li  4
Affiliations

Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma

Xiaoxia Dai et al. Pak J Med Sci. 2020 Nov-Dec.

Abstract

Objective: To analyze the clinical effect of budesonide/fomoterol combined with montelukast in the treatment of chronic persistent asthma.

Methods: Ninety-four patients with asthma who came to our hospital for treatment from April 2017 to April 2019 were randomly divided into control group and observation group, with 47 patients in each group. The control group was treated with budesonide/formoterol, and the observation group was treated with montelukast on the basis of the control group. The treatment effect of the two groups was observed and compared.

Results: The total efficacy rate of the observation group was significantly higher than that of the control group (P<0.05); the daytime symptom score and nighttime symptom score of the observation group were significantly higher than those of the control group (P<0.05). The pulmonary function indexes of the two groups after treatment were significantly higher than that before treatment, and the improvement of the observation group was more significant (P<0.05); the FeNO and EO levels of the observation group after treatment were superior to those of the control group, and the difference was statistically significant (P<0.05).

Conclusion: Budesonide/formoterol powder inhalation combined with montelukast can effectively improve the lung function, reduce the level of inflammatory factors, and accelerate the regression of symptoms in the treatment of chronic persistent asthma. It is worth clinical application.

Keywords: Bronchial asthma; Budesonide/formoterol; Montelukast; Pulmonary function.

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References

    1. Shahin MYA, El-Lawah AA, Amin A, El-Tawil I AH. Study of serum vitamin D level in adult patients with bronchial asthma. Egypt J Chest Dis Tub. 2017;66(1):5–9. doi:10.1016/j.ejcdt.2016.11.005.
    1. Liu Y, Zhang H, Ni R, Jia WQ, Wang YY. IL-4R suppresses airway inflammation in bronchial asthma by inhibiting the IL-4/STAT6 pathway. Pulm Pharmacol Ther. 2017;43:32–38. doi:10.1016/j.pupt.2017.01.006. - PubMed
    1. Sweileh WM, Aljabi SW, Zyoud SH, Sawalha AF. Bronchial asthma and chronic obstructive pulmonary disease:research activity in Arab countries. Multidiscip Resp Med. 2014;9(1):38. doi:10.1186/2049-6958-9-38. - PMC - PubMed
    1. Fatani SH. Biomarkers of oxidative stress in acute and chronic bronchial asthma. J Asthma. 2014;51(6):578–584. doi:10.3109/02770903.2014.892965. - PubMed
    1. Yadav M, Mittal K. Effect of vitamin D supplementation on moderate to severe bronchial asthma. Indian J Pediatr. 2014;81(7):650–654. doi:10.1007/s12098-013-1268-4. - PubMed

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