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Comment
. 2020;2(1):e200005.
doi: 10.20900/immunometab20200005. Epub 2020 Jan 10.

CD4 T Cell Metabolism Is a Major Contributor of HIV Infectivity and Reservoir Persistence

Harry E Taylor  1 , Clovis S Palmer  2   3
Affiliations
Comment

CD4 T Cell Metabolism Is a Major Contributor of HIV Infectivity and Reservoir Persistence

Harry E Taylor et al. Immunometabolism. 2020.

Abstract

HIV infection is characterized by elevated glycolytic metabolism in CD4 T cells. In their recent study, Valle-Casuso et al. demonstrated that both increased glucose utilization and glutamine metabolism are essential for HIV infectivity and replication in CD4 T cells. Here, we discuss the broader implications of immunometabolism in studies of HIV persistence and their potential to inform new treatment and curative strategies.

Keywords: CD4 T cells; HIV; HIV cure; immune activation; immunometabolism; metabolism.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no conflicts of interest.

Figures

Figure 1.
Figure 1.. Valle-Casuso and colleagues showed susceptibility of CD4 T cells to HIV infection is dependent on CD4 T cell metabolic activity.
Activation of CD4 T cells in the presence of drugs that block glycolysis (2-DG: 2-deoxy-glucose) or glutamine metabolism (DON: 6-Diazo-5-oxo-L-norleucine), renders CD4 T cells resistant to HIV, while inducing death of infected cells. Elevated metabolism while providing substrates for HIV transcription also deliver building blocks for nucleotide synthesis essential for proliferation of CD4 reservoir cells.
See this image and copyright information in PMC

Comment on

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