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. 2021 Apr;24(2):262-268.
doi: 10.1007/s11102-020-01106-3. Epub 2020 Nov 24.

The direct and indirect impact of the COVID-19 pandemic on the care of patients with pituitary disease: a cross sectional study

Anneke Graf  1 , Hani J Marcus  2 , Stephanie E Baldeweg  3   4
Affiliations

The direct and indirect impact of the COVID-19 pandemic on the care of patients with pituitary disease: a cross sectional study

Anneke Graf et al. Pituitary. 2021 Apr.

Abstract

Purpose: The coronavirus disease 2019 (COVID-19) pandemic is widely believed to have had a major impact on the care of patients with pituitary disease. The virus itself may directly result in death, and patients with adrenal insufficiency, often a part of hypopituitarism, are thought to represent a particularly susceptible subgroup. Moreover, even in patients that do not contract the virus, the diversion of resources by healthcare institutions to manage the virus may indirectly result in delays in their management. To this end, the aim of this study was to determine the direct and indirect impact of the COVID-19 pandemic on patients with pituitary disease.

Methods: A cross-sectional study design was adopted, with all adult patients seen by our pituitary service in the year prior to the nationwide lockdown on March 23rd 2020 invited to participate in a telephone survey.

Results: In all, 412 patients (412/586; 70.3%) participated in the survey. 66 patients (66/412; 16.0%) reported having suspected COVID-19 infection. Of the 10 patients in this group tested for COVID-19 infection, three received a positive test result. No deaths due to COVID-19 were identified. 267 patients (267/412; 64.8%) experienced a delay or change in the planned care for their pituitary disease, with 100 patients (100/412; 24.3%) perceiving an impact to their care.

Conclusions: Whilst only a small percentage of patients had confirmed or suspected COVID-19 infection, over half were still indirectly impacted by the pandemic through a delay or change to their planned care.

Keywords: COVID-19; Direct; Impact; Indirect; Pandemic; Pituitary.

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Conflict of interest statement

All authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Patient survey
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References

    1. Fleseriu M, Buchfelder M, Cetas JS, et al. Pituitary society guidance: pituitary disease management and patient care recommendations during the COVID-19 pandemic—an international perspective. Pituitary. 2020;23:327–337. doi: 10.1007/s11102-020-01059-7. - DOI - PMC - PubMed
    1. Puig-Domingo M, Marazuela M, Giustina A (2020) COVID-19 and endocrine diseases. A statement from the European Society of Endocrinology. European Endocrine Society. https://www.ese-hormones.org/media/2223/covid-and-endocrine-diseases-ese.... Accessed 1 July 2020 - PMC - PubMed
    1. Stewart PM, Biller BM, Marelli C, et al. Exploring inpatient hospitalizations and morbidity in patients with adrenal insufficiency. J Clin Endocrinol. 2016;101:4843–4850. doi: 10.1210/jc.2016-2221. - DOI - PubMed
    1. Arlt W, Baldeweg SE, Pearce S et al Endocrinology in the time of COVID-19: management of adrenal insufficiency. J Endocrinol 183(1):G25–G32. https://eje.bioscientifica.com/view/journals/eje/183/1/EJE-20-0361.xml - PMC - PubMed
    1. Government of the United Kingdom (2020) Cases in United Kingdom. https://coronavirus.data.gov.uk/cases. Accessed 25 Oct 2020

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