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Review
. 2021 Aug;278(8):3045-3053.
doi: 10.1007/s00405-020-06482-x. Epub 2020 Nov 25.

Prognostic outcomes of treatment naïve oral tongue squamous cell carcinoma (OTSCC): a comprehensive analysis of 14 years

Muhammad Faisal  1 , Rahim Dhanani  2 , Sami Ullah  2 , Muhammad Abu Bakar  3 , Nabia Irfan  4 , Kashif Iqbal Malik  2 , Asif Loya  5 , Erovic M Boban  6 , Raza Hussain  2 , Arif Jamshed  4
Affiliations
Review

Prognostic outcomes of treatment naïve oral tongue squamous cell carcinoma (OTSCC): a comprehensive analysis of 14 years

Muhammad Faisal et al. Eur Arch Otorhinolaryngol. 2021 Aug.

Erratum in

Abstract

Objectives: To analyze the factors predicting survival outcomes in treatment naïve oral tongue squamous cell carcinoma (OTSCC).

Materials and methods: A comprehensive review of 531 oral tongue carcinoma patients treated with upfront surgery followed by adjuvant radiotherapy or chemoradiotherapy was conducted from 2004-2018.

Results: The mean age of presentation was 53 years (11-86) with a male to female ratio of 1.3:1. The associated risk factors were smoking (21%), betel nut (16%), naswar (9%) and alcohol (1%). Most of the cases were either well (45.1%) or moderately (46.2%) differentiated. Surgery was performed in 164 patients alone while 368 were treated with surgery in combination with adjuvant modalities. Overall (OS) and disease free survival (DFS) were 66 and 71%, respectively, with a median follow up of 2.5 years. Cox regression analysis showed nodal positivity, increased depth of invasion (DOI) and higher lymph node ratio (LNR) as significant prognosticators impacting OS and DSS.

Conclusion: Nodal volume, DOI and LNR are the most consistent predictors of poor outcome in OTSCC. Nodal positivity, depth of invasion > 5 mm and lymph node ratio > 0.04 adversely affect OS and DSS.

Keywords: Depth of invasion; Lymph node ratio; Nodal volume; Oral tongue cancer; Predictors of survival.

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References

    1. Marra A, Violati M, Broggio F, Codecà C, Blasi M, Luciani A et al (2019) Long-term disease-free survival in surgically-resected oral tongue cancer: a 10-year retrospective study. Acta Otorhinolaryngol Ital 39(2):84 - DOI
    1. Patel SC, Carpenter WR, Tyree S, Couch ME, Weissler M, Hackman T et al (2011) Increasing incidence of oral tongue squamous cell carcinoma in young white women, age 18 to 44 years. J Clin Oncol 29(11):1488–1494 - DOI
    1. Ng JH, Iyer NG, Tan MH, Edgren G (2017) Changing epidemiology of oral squamous cell carcinoma of the tongue: a global study. Head Neck 39(2):297–304 - DOI
    1. Bello IO, Soini Y, Salo T (2010) Prognostic evaluation of oral tongue cancer: means, markers and perspectives (II). Oral Oncol 46(9):636–643 - DOI
    1. van Dijk BA, Brands MT, Geurts SM, Merkx MA, Roodenburg JL (2016) Trends in oral cavity cancer incidence, mortality, survival and treatment in the Netherlands. Int J Cancer 139(3):574–583 - DOI

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