Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Nov;31 Suppl 26(Suppl 26):63-65.
doi: 10.1111/pai.13358.

HMGB1: A pleiotropic activity

Laura Colavita  1 , Giorgio Ciprandi  2 , Annamaria Salpietro  3 , Caterina Cuppari  1
Affiliations

HMGB1: A pleiotropic activity

Laura Colavita et al. Pediatr Allergy Immunol. 2020 Nov.

Abstract

High-mobility group box 1 (HMGB1) is a nuclear protein involved in DNA replication, transcription, recombination, and repair. In the extracellular space, the HMGB1 plays an essential role in the onset and perpetuation of inflammation, belonging to the group of damage-associated molecular pattern (DAMP) molecules, also called alarmins. For this, HMGB1 has been studied in several acute and chronic inflammatory diseases as an early biomarker of inflammation. An increased concentration of HMGB1 has been detected in serum, as the expression of systemic inflammation, and in specific samples (such as stool, synovial fluid, nasal lavage fluid, sputum, and cerebrospinal fluid), as the expression of local production, in several infectious and/or inflammatory diseases. These data are particularly important because they open new futuristic possibilities for target therapies, potentially also for the COVID-19 treatment.

Keywords: HMGB1; biomarker; inflammation; target therapy.

PubMed Disclaimer

Conflict of interest statement

All authors (Laura Colavita, Giorgio Ciprandi, Annamaria Salpietro, Caterina Cuppari) declare no conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mandke P, Vasquez KM. Interactions of high mobility group box protein 1 (HMGB1) with nucleic acids: Implications in DNA repair and immune responses. DNA Repair (Amst). 2019;83:102701. - PMC - PubMed
    1. Yang H, Wang H, Andersson U. Targeting inflammation driven by HMGB1. Front Immunol. 2020;20(11):484. - PMC - PubMed
    1. Chirico V, Lacquaniti A, Salpietro V, et al. High‐mobility group box 1 (HMGB1) in childhood: from bench to bedside. Eur J Pediatr. 2014;173(9):1123‐1136. - PubMed
    1. Cheng Z, Kang Y, Wu QG, et al. Levels of HMGB1 in induced sputum from patients with asthma and chronic obstructive pulmonary disease. Zhonghua Yi Xue Za Zhi. 2011;91(42):2981‐2984. - PubMed
    1. Chirico V, Lacquaniti A, Leonardi S, et al. Acute pulmonary exacerbation and lung function decline in patients with cystic fibrosis: high‐mobility group box 1 (HMGB1) between inflammation and infection. Clin Microbiol Infect. 2015;21(4):368.e1‐368.e9. - PubMed