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. 2021 Mar;22(3):405-414.
doi: 10.3348/kjr.2020.0518. Epub 2020 Nov 3.

Clinically Available Software for Automatic Brain Volumetry: Comparisons of Volume Measurements and Validation of Intermethod Reliability

Ji Young Lee  1 , Se Won Oh  2 , Mi Sun Chung  3 , Ji Eun Park  4 , Yeonsil Moon  5 , Hong Jun Jeon  6 , Won Jin Moon  7
Affiliations

Clinically Available Software for Automatic Brain Volumetry: Comparisons of Volume Measurements and Validation of Intermethod Reliability

Ji Young Lee et al. Korean J Radiol. 2021 Mar.

Abstract

Objective: To compare two clinically available MR volumetry software, NeuroQuant® (NQ) and Inbrain® (IB), and examine the inter-method reliabilities and differences between them.

Materials and methods: This study included 172 subjects (age range, 55-88 years; mean age, 71.2 years), comprising 45 normal healthy subjects, 85 patients with mild cognitive impairment, and 42 patients with Alzheimer's disease. Magnetic resonance imaging scans were analyzed with IB and NQ. Mean differences were compared with the paired t test. Inter-method reliability was evaluated with Pearson's correlation coefficients and intraclass correlation coefficients (ICCs). Effect sizes were also obtained to document the standardized mean differences.

Results: The paired t test showed significant volume differences in most regions except for the amygdala between the two methods. Nevertheless, inter-method measurements between IB and NQ showed good to excellent reliability (0.72 < r < 0.96, 0.83 < ICC < 0.98) except for the pallidum, which showed poor reliability (left: r = 0.03, ICC = 0.06; right: r = -0.05, ICC = -0.09). For the measurements of effect size, volume differences were large in most regions (0.05 < r < 6.15). The effect size was the largest in the pallidum and smallest in the cerebellum.

Conclusion: Comparisons between IB and NQ showed significantly different volume measurements with large effect sizes. However, they showed good to excellent inter-method reliability in volumetric measurements for all brain regions, with the exception of the pallidum. Clinicians using these commercial software should take into consideration that different volume measurements could be obtained depending on the software used.

Keywords: Alzheimer's disease; Brain volumetry; MRI; NeuroQuant®; Reliability; Softwares.

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1. Flow chart of the study population.
AD = Alzheimer's disease, MCI = mild cognitive impairment
Fig. 2
Fig. 2. Representative images of the color-coded images of NQ and IB.
An axial T1-weighted image (A) is shown at basal ganglia level with color-coded images of NQ (B) and IB (C). In these representative images, the pallidum in NQ appears smaller (B) compared to that in IB (C), while the putamen in NQ appears larger (B) than that in IB (C). The pallidum is indicated with asterisks. IB = Inbrain®, NQ = NeuroQuant®
See this image and copyright information in PMC

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