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. 2020 Nov 23;25(22):5469.
doi: 10.3390/molecules25225469.

Anacyclus pyrethrum (L): Chemical Composition, Analgesic, Anti-Inflammatory, and Wound Healing Properties

Fatima Zahra Jawhari  1 , Abdelfattah El Moussaoui  1 , Mohammed Bourhia  2 , Hamada Imtara  3 , Hamza Mechchate  1 , Imane Es-Safi  1 , Riaz Ullah  4 , Essam Ezzeldin  5 , Gamal A Mostafa  5 , Andriy Grafov  6 , Samir Ibenmoussa  2 , Dalila Bousta  1 , Amina Bari  1
Affiliations

Anacyclus pyrethrum (L): Chemical Composition, Analgesic, Anti-Inflammatory, and Wound Healing Properties

Fatima Zahra Jawhari et al. Molecules. .

Abstract

Background: Anacyclus pyrethrum (A. pyrethrum) is a wild species belonging to the family Asteraceae, which is used in traditional medicines.

Aim of the study: This work was undertaken to study the chemical composition, analgesic, anti-inflammatory, and wound healing properties of hydroalcoholic extracts of different parts (roots, seeds, leaves, and capitula) of A. pyrethrum. Material and Methods: The phytochemical analysis of the studied extracts was conducted by GC-MS. The analgesic activity was evaluated in mice using acetic acid and formaldehyde methods. The anti-inflammatory activity was tested using the inhibitory method of edema induced in rats. The healing activity of the hydroethanolic extracts was explored by excision and incision wound healing models in rats.

Results: The phytochemical analysis of the studied plant extracts affirmed the presence of interesting compounds, including some newly detected elements, such as sarcosine, N-(trifluoroacetyl)-butyl ester, levulinic acid, malonic acid, palmitic acid, morphinan-6-One, 4,5.alpha.-epoxy-3-hydroxy-17-methyl, 2,4-undecadiene-8,10-diyne-N-tyramide, and isovaleric acid. The extracts of different parts (roots, seeds, leaves, and capitula) exhibited promising anti-inflammatory, analgesic, and wound healing effects, with percentages of inhibition up to 98%, 94%, and 100%, respectively.

Conclusion: This study might contribute towards the well-being of society as it provides evidence on the potential analgesic, anti-inflammatory, and wound healing properties of A. pyrethrum.

Keywords: Anacyclus pyrethrum (L); GC-MS analysis; analgesic; anti-inflammatory; wound healing.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Chromatographic profile of different extracts (roots, seeds, leaves, and capitula) of A. pyrethrum (L).
See this image and copyright information in PMC

References

    1. Ekor M. The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. Front. Pharmacol. 2014;4:177. doi: 10.3389/fphar.2013.00177. - DOI - PMC - PubMed
    1. Chabrier J.-Y. Ph.D. Thesis. Universite Henri Poincare—Nancy 1; Nancy, France: 2010. Plantes médicinales et formes d’utilisation en phytothérapie.
    1. Verpoorte R. La pharmacognosie du nouveau millénaire: Pistes et biotechnologie. In: Fleurentin J., Mazars G., Pelt J.-M.> , editors. Des Sources du Savoir Aux Médicaments du Future. IRD Éditions; Marseille, France: 2014. pp. 263–274.
    1. Fennane M. Eléments pour un Livre rouge de la flore vasculaire du Maroc. Fasc. 3. Asteraceae. [(accessed on 18 October 2020)];Tela-Botanica. 2017 3 Available online: https://www.tela-botanica.org/wp-content/uploads/2017/05/Tela-Bot_LivreR....
    1. Fennane M., Ibn Tattou J.M., Oualidi E. Flore Pratique du Maroc. Volume 3 Institut Scientifique; Rabat, Morocco: 2014.

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