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. 1987 Oct 29;81(3):285-90.
doi: 10.1016/0304-3940(87)90397-1.

Helium pressure potentiates the N-methyl-D-aspartate- and D,L-homocysteate-induced decreases of field potentials in the rat hippocampal slice preparation

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Helium pressure potentiates the N-methyl-D-aspartate- and D,L-homocysteate-induced decreases of field potentials in the rat hippocampal slice preparation

L Fagni et al. Neurosci Lett. .

Abstract

We examined the influence of helium pressure on the depression induced by various excitatory amino acids in CA1 hippocampal field potentials. The effects of quisqualate, L-glutamate, L-aspartate and kainate were not significantly affected by helium pressure, while those of N-methyl-D-aspartate and D,L-homocysteate were enhanced. These findings suggest that helium pressure specifically increased the sensitivity of the N-methyl-D-aspartate receptor type in the hippocampus. Other hypotheses are discussed.

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