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Comment
. 2021 Dec;35(12):3442-3444.
doi: 10.1038/s41433-020-01283-2. Epub 2020 Nov 25.

Reply to Editorial: Interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication

Paula M Marinho  1   2 , Heloisa Nascimento  3   4 , Allexya A A Marcos  1   2 , André C Romano  1   2 , Richard B Rosen  5 , Rubens Belfort Jr  1   2
Affiliations
Comment

Reply to Editorial: Interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication

Paula M Marinho et al. Eye (Lond). 2021 Dec.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1. Fundus picture from right eye of previously published patient (Marinho et al. [1]).
The pictures were taken 3 months after first evaluation and shows the absence of the previously reported cotton wool spot lesion.
Fig. 2
Fig. 2. Composite with color fundus photograph (a) and a B-scan OCT (e) of the right eye of patient with preovius COVID-19 diagnosis.
The images depict a hyperreflective lesion at the level of the inner plexiform and ganglion cell layer (yellow arrows), which aligns with inferior lesion at the enface OCT image as highlighted by in red line (c, d, e). The OCT-angiography indicates no flow void at that same site (b). The red dot flow overlay on the B scan OCT image, based upon OCT angiogram data, differentiates this lesion (green arrow) and from an adjacent blood vessel cross-section by the presence of the red overlay within the lumen marking active blood flow (blue arrow). The density within the vessel results in a shadow projected deep into the underlying retinal layers (d), which the lesion produces no shadow artifact.
Fig. 3
Fig. 3. A composite with fundus exam and OCT from the same patient from Fig. 2 showing lesion’s evolution.
a1 and a2 were taken on 1st evaluation, b1 and b2 were taken after 37 days. c1 and c2 were taken after another 28 days.
See this image and copyright information in PMC

Comment on

  • Retinal findings in patients with COVID-19.
    Marinho PM, Marcos AAA, Romano AC, Nascimento H, Belfort R Jr. Marinho PM, et al. Lancet. 2020 May 23;395(10237):1610. doi: 10.1016/S0140-6736(20)31014-X. Epub 2020 May 12. Lancet. 2020. PMID: 32405105 Free PMC article. No abstract available.

References

    1. Marinho PM, Marcos AAA, Romano AC, Nascimento H, Belfort R. Retinal findings in patients with COVID-19. Lancet. 2020. 10.1016/S0140-6736(20)31014-X. - PMC - PubMed
    1. Vavvas DG, Sarraf D, Sadda SR. Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication. Eye (Lond) 2020;9:1–2. - PMC - PubMed
    1. Virgo J, Mohamed M. Paracentral acute middle maculopathy and acute macular neuroretinopathy following SARS-CoV-2 infection. Eye. 2020. 10.1038/s41433-020-1069-8. - PMC - PubMed
    1. Landecho MF, Yuste JR, Gándara E, Sunsundegui P, Alcaide AB, García-Layana A. COVID-19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease? J Intern Med. 2020. 10.1111/joim.13156. - PubMed
    1. Insausti-García A, Reche-Sainz JA, Ruiz-Arranz C, López Vázquez Á, Ferro-Osuna M. Papillophlebitis in a COVID-19 patient: Inflammation and hypercoagulable state. Eur J Ophthalmol. 2020:1120672120947591. 10.1177/1120672120947591. - PMC - PubMed