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Case Reports
. 2020 Nov 4:14:100228.
doi: 10.1016/j.lrr.2020.100228. eCollection 2020.

Use of Tocilizumab in Management of Post-Operative Myelomonocytic Leukemoid Reaction

Megan Melody  1 , Emily Butts  1 , David Menke  2 , Kevin Landolfo  3 , Keith Oken  4 , Taimur Sher  5 , Sharad Khurana  6
Affiliations
Case Reports

Use of Tocilizumab in Management of Post-Operative Myelomonocytic Leukemoid Reaction

Megan Melody et al. Leuk Res Rep. .

Erratum in

Abstract

Interleukin 6 receptor (IL6R) inhibitor, tocilizumab, has been effectively used in the treatment of cytokine release syndrome in patients receiving chimeric antigen receptor T-cell therapy. Here we present a patient with chronic myelomonocytic leukemia (CMML) who developed a steroid refractory, post-operative myelomonocytic leukemoid reaction (PO-MMLR), effectively treated with tocilizumab. Although, further studies are needed to validate the effectiveness of tocilizumab in management of PO-MMLR, this case serves to provide a new management approach in treatment of this rare but lethal syndrome with no standardized treatment options.

Keywords: Chronic myelomonocytic leukemia; Leukemoid reaction; Systemic inflammatory response; Tocilizumab.

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