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Review
. 2021 Jan:146:110396.
doi: 10.1016/j.mehy.2020.110396. Epub 2020 Nov 17.

Same pollution sources for climate change might be hyperactivating the NLRP3 inflammasome and exacerbating neuroinflammation and SARS mortality

David Macias-Verde  1 , Pedro C Lara  2 , Javier Burgos-Burgos  3
Affiliations
Review

Same pollution sources for climate change might be hyperactivating the NLRP3 inflammasome and exacerbating neuroinflammation and SARS mortality

David Macias-Verde et al. Med Hypotheses. 2021 Jan.

Abstract

We have reviewed a considerable amount of recent scientific papers relating inflammation caused by air pollution with chronic and severe medical conditions. Furthermore, there are evidences relating organ inflammation caused by not only outdoor long-term but also short-term inhaled radioisotopes contained in high polluted air or in household natural radioactive background aerosols, in addition to SARS-COV-2 attached to bioaerosols, which are related with a worst evolution of severe acute respiratory syndrome patients. Reactive oxygen species (ROS) production induced by the interaction with environmental ionizing radiation contained in pollution is pointed out as a critical mechanism that predispose mainly to elder population, but not excluding young subjects, presenting previous chronic conditions of lung inflammation or neuroinflammation, which can lead to the most serious consequences.

Keywords: ARDS; Alzheimer’s disease; COVID-19; NLRP3 inflammasome; Pollution; Radioactivity.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Particulate matter diameter comparison. Source: United States Environmental Protection Agency (USEPA).
Fig. 2
Fig. 2
Tropospheric nitrogen dioxide concentrations over Europe between March and April 2019. Levels are the same over the last few years. Copernicus Sentinel-5P (https://maps.s5p-pal.com/).
Fig. 3
Fig. 3
Natural background radiation worldwide (https://ppt-online.org/303224).
Fig. 4
Fig. 4
Age-standardized prevalence for Alzheimer’s disease worldwide.
Fig. 5
Fig. 5
Cumulative confirmed cases last updated 10/8/2020 10:23 a. m. Source: John Hopkins University of Medicine. (https://coronavirus.jhu.edu/map.html). India, Brazil, and Iran are in between the most affected countries in the world.
Fig. 6
Fig. 6
NASA resource (https://images.app.goo.gl/WM4B3LCz2GgZWeqo8).
Fig. 7
Fig. 7
Tenerife Auditorium near view through dense dust. Santa Cruz de Tenerife. February 2020 (https://images.app.goo.gl/XJfwnsRTgxAemws77).
See this image and copyright information in PMC

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