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Observational Study
. 2020 Nov 26;10(11):e037034.
doi: 10.1136/bmjopen-2020-037034.

Impact of the zero-mark-up drug policy on drug-related expenditures and use in public hospitals, 2016-2018: an interrupted time series study in Shaanxi

Kangkang Yan  1   2 , Caijun Yang  1 , Hongli Zhang  3 , Dan Ye  2 , Shengyuan Liu  2 , Jie Chang  1 , Minghuan Jiang  1 , Mingyue Zhao  1 , Yu Fang  4
Affiliations
Observational Study

Impact of the zero-mark-up drug policy on drug-related expenditures and use in public hospitals, 2016-2018: an interrupted time series study in Shaanxi

Kangkang Yan et al. BMJ Open. .

Abstract

Objective: The aim of this study was to measure the impact of zero-mark-up drug policy (ZMDP) on drug-related expenditures and use in urban hospitals.

Design: This was a retrospective observational study of trends in drug expenses and use in the context of the ZMDP using an interrupted time series analysis.

Setting: Twelve hospitals (three tertiary hospitals and nine secondary hospitals) in Xi'an, which is the capital of Shaanxi Province in Western China.

Data and participants: The prescription information for all outpatients and inpatients in the study hospitals from January 2016 to April 2018 was used in this study.

Interventions: The Chinese government announced the policy intervention measure of the ZMDP, which was implemented in all public hospitals as of 1 April 2017.

Primary measures: Monthly drug expenditures, monthly medical expenditures, the percentage of drug expenditures among total medical expenditures, the average outpatient drug expenditure per visit, the percentage of prescriptions that include an injection and the percentage of prescriptions that include an antibiotic.

Results: Monthly total medical expenses increased in both tertiary and secondary hospitals after the ZMDP was implemented. In tertiary hospitals, the average outpatient drug expenditures per visit showed a slow decreasing trend before the intervention and an increasing trend after the intervention, with statistically significant changes in both the level (p<0.001) and the trend (p=0.02). Secondary hospitals showed a slow increasing trend both before and after the policy implementation, with no significant change in the trend (p=0.205). The proportion of prescriptions, including injections, was over 20% in secondary hospitals and less than 20% in tertiary hospitals, with no significant changes to this indicator observed after implementation of ZMDP.

Conclusions: The effect of the ZMDP on drug-related expenditures and use in Chinese public hospitals was not substantially evident. Future pharmaceutical reform measures should give more consideration to physician prescription behaviours.

Keywords: China; drug expenditure; drug use; hospital; interrupted time series analysis; zero mark-up drug policy.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Change of the percentage of drug expenditures to total medical expenditure from January 2016 to April 2018.
Figure 2
Figure 2
Change of the monthly drug expenditures in tertiary hospitals from January 2016 to April 2018.
Figure 3
Figure 3
Change of the monthly medical expenditure in tertiary hospitals from January 2016 to April 2018.
Figure 4
Figure 4
Change of the monthly drug expenditures in secondary hospitals from January 2016 to April 2018.
Figure 5
Figure 5
Change of the monthly medical expenditure in secondary hospitals from January 2016 to April 2018.
Figure 6
Figure 6
Change of the average outpatient drug expenditure per visit from January 2016 to April 2018.
Figure 7
Figure 7
Change of the percentage of prescriptions including an injection from January 2016 to April 2018.
Figure 8
Figure 8
Change of the percentage of prescriptions including an antibiotic from January 2016 to April 2018.
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