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Comment
. 2021 Feb;18(2):243-244.
doi: 10.1038/s41423-020-00584-6. Epub 2020 Nov 26.

New strategy for COVID-19 vaccination: targeting the receptor-binding domain of the SARS-CoV-2 spike protein

Junzhi Wang  1
Affiliations
Comment

New strategy for COVID-19 vaccination: targeting the receptor-binding domain of the SARS-CoV-2 spike protein

Junzhi Wang. Cell Mol Immunol. 2021 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declare no competing interests.

Figures

Fig. 1
Fig. 1
A recombinant vaccine targeting the receptor-binding domain (RBD) of the SARS-CoV-2 spike can induce a protective immune response. The recombinant RBD protein was expressed in insect cells using the Bac-to-Bac system and Alum-precipitated for vaccine formulation. After the vaccination of the nonhuman primate monkeys with the RBD vaccine, serum antibodies that could bind the RBD and neutralize viral infection were effectively induced, providing the rationale for the development of a protective vaccine through the induction of antibodies against the RBD
See this image and copyright information in PMC

Comment on

  • A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity.
    Yang J, Wang W, Chen Z, Lu S, Yang F, Bi Z, Bao L, Mo F, Li X, Huang Y, Hong W, Yang Y, Zhao Y, Ye F, Lin S, Deng W, Chen H, Lei H, Zhang Z, Luo M, Gao H, Zheng Y, Gong Y, Jiang X, Xu Y, Lv Q, Li D, Wang M, Li F, Wang S, Wang G, Yu P, Qu Y, Yang L, Deng H, Tong A, Li J, Wang Z, Yang J, Shen G, Zhao Z, Li Y, Luo J, Liu H, Yu W, Yang M, Xu J, Wang J, Li H, Wang H, Kuang D, Lin P, Hu Z, Guo W, Cheng W, He Y, Song X, Chen C, Xue Z, Yao S, Chen L, Ma X, Chen S, Gou M, Huang W, Wang Y, Fan C, Tian Z, Shi M, Wang FS, Dai L, Wu M, Li G, Wang G, Peng Y, Qian Z, Huang C, Lau JY, Yang Z, Wei Y, Cen X, Peng X, Qin C, Zhang K, Lu G, Wei X. Yang J, et al. Nature. 2020 Oct;586(7830):572-577. doi: 10.1038/s41586-020-2599-8. Epub 2020 Jul 29. Nature. 2020. PMID: 32726802

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