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Review
. 2020 Nov 7;26(41):6322-6334.
doi: 10.3748/wjg.v26.i41.6322.

Focus on gastroesophageal reflux disease in patients with cystic fibrosis

Annarita Bongiovanni  1 , Sara Manti  2 , Giuseppe Fabio Parisi  1 , Maria Papale  1 , Enza Mulè  1 , Novella Rotolo  1 , Salvatore Leonardi  1
Affiliations
Review

Focus on gastroesophageal reflux disease in patients with cystic fibrosis

Annarita Bongiovanni et al. World J Gastroenterol. .

Abstract

Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder in cystic fibrosis (CF), and based on various studies, its prevalence is elevated since childhood. There are several pathogenetic mechanisms on the basis of association between CF and GERD. However, there are no specific guidelines for GERD in CF patients, so diagnosis is based on guidelines performed on patients not affected by CF. The aim of this review is to provide the pathophysiology, diagnostic and therapeutic options, complications, and future directions in the management of GERD patients with CF.

Keywords: Adult; Children; Cystic Fibrosis; Gastroesophageal reflux.

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Conflict of interest statement

Conflict-of-interest statement: The authors have no conflicts of interest to disclose that could be perceived as prejudicing the impartiality of the research reported.

Figures

Figure 1
Figure 1
Flow-chart on management of gastroesophageal reflux disease in cystic fibrosis patients. PPI: Proton pump inhibitor.
See this image and copyright information in PMC

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