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. 2020 Sep 17:37:70.
doi: 10.11604/pamj.2020.37.70.20223. eCollection 2020.

[CD10 expression in stromal cells of patients with breast cancer: a poor prognostic marker]

[Article in French]
Dhouha Bacha  1 , Anissa Ben Amor  2 , Farah Ben Farhat  1 , Sana Ben Slama  1 , Ahlem Lahmar  1 , Saadia Bouraoui  1 , Amel Triki  2
Affiliations

[CD10 expression in stromal cells of patients with breast cancer: a poor prognostic marker]

[Article in French]
Dhouha Bacha et al. Pan Afr Med J. .

Abstract
in English, French

Introduction: markers in breast cancer stem cells, such as cluster of differentiation 10 (CD10), would be correlated with invasive and metastatic potential of several types of cancer, contributing to tumor growth and metastases. In patients with breast cancer, its prognostic value is still controversial, given the discrepancy of results. The purpose of the study was to study CD10 expression in stromal cells of patients with breast cancer as well as to evaluate the prognostic value of this expression.

Method: we conducted a retrospective, descriptive and prognostic study. It involved 57 patients with invasive cancer of no special type, whose data were collected in the Department of Pathological Anatomy at the Mongi Slim Hospital over a 38-month period. CD10 expression was studied immunohistochemically and interpreted by semi-quantitative scoring system based on three categories with thresholds of 10 and 30%.

Results: the average age of patients was 56.4 years. Twenty-eight patients (49%) had labeled CD10 stromal, half of patients had a score of 1 (low) and the other half had 2 (high). This labeling significantly reduced recurrence-free survival (p=0.001). However, it had no influence on overall survival (p=0.84). The correlation study showed that CD10 expression in stromal cells was significantly correlated with 12 poor prognostic factors in patients with breast cancer.

Conclusion: CD10 expression in stromal cells of invasive breast cancer is a poor prognostic factor, predictive of poor survival without recurrence and associated with a high invasive and metastatic potential.

Introduction: les marqueurs du stroma carcinomateux comme la classe de différenciation 10 (CD10) seraient corrélés à un potentiel invasif et métastatique de plusieurs types de cancers en favorisant la croissance tumorale et l’apparition de métastases. Pour les carcinomes mammaires, sa valeur pronostique reste encore controversée avec des résultats discordants. Les objectifs de notre étude étaient d’étudier l’expression stromale de CD10 dans les carcinomes mammaires et d’évaluer la valeur pronostique de cette expression.

Méthodes: notre étude était rétrospective, descriptive et pronostique. Elle avait intéressé 57 patientes porteuses de carcinomes invasifs de type non spécifique, colligés au service d’anatomie pathologique de l’hôpital Mongi Slim, sur une période de 38 mois. L’étude de CD10 a été réalisée par immunohistochimie et son interprétation était basée sur un score semi-quantitatif en trois catégories avec des seuils de 10 et 30%.

Résultats: l’âge moyen de nos patientes était de 56,4 ans. Vingt-huit patientes (49%) avaient un marquage stromal de CD10, la moitié était de score 1 (faible) et l’autre moitié de score 2 (fort). Ce marquage diminuait significativement la survie sans récidives (p=0,001). Il n’y a en revanche pas d’influence sur la survie globale (p=0,84). L’étude de corrélation avait montré que l’expression stromale de CD10 était significativement corrélée à 12 facteurs de mauvais pronostic dans les cancers du sein.

Conclusion: l’expression de CD10 dans le stroma des carcinomes mammaires invasifs constitue un facteur de mauvais pronostic, prédictif d’une faible survie sans récidives et est associée à un potentiel invasif et métastatique élevé.

Keywords: Breast cancer; CD10; prognostic; stromal cells.

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Conflict of interest statement

Les auteurs ne déclarent aucun conflit d’intérêts.

Figures

Figure 1
Figure 1
A) expression du CD10 dans les carcinomes mammaires (CD4x200); témoin interne: marquage des cellules myoépithéliales des acini du parenchyme mammaire normal; B) score 0: marquage de moins de 10% des cellules stromales; C) score 1: marquage de 25% des cellules stromales; D) score 2: expression de 80% des cellules stromales
Figure 2
Figure 2
courbes de la survie sans récidives en fonction de l’expression stromale de CD10
See this image and copyright information in PMC

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