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Editorial
. 2021 Jul 15;73(2):352-353.
doi: 10.1093/cid/ciaa1325.

How Could In Vitro Antiviral Activity Be Applied to Optimize the Dosing Regimens of Candidates for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)?

Ranran Jia  1 , Hongyun Wang  1
Affiliations
Editorial

How Could In Vitro Antiviral Activity Be Applied to Optimize the Dosing Regimens of Candidates for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)?

Ranran Jia et al. Clin Infect Dis. .
No abstract available

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Figures

Figure 1.
Figure 1.
Bridging of antiviral activity in vitro and the concentration in vivo. Abbreviation: EC50 value, half-maximal effective concentration.
See this image and copyright information in PMC

Comment in

  • Response to Jia and Wang.
    Liu X, Liu Q, Yao X, Zhang M, Cui C, Li H, Liu D. Liu X, et al. Clin Infect Dis. 2021 Jul 15;73(2):352-353. doi: 10.1093/cid/ciaa1390. Clin Infect Dis. 2021. PMID: 33170206 Free PMC article. No abstract available.

Comment on

  • Response to Jia and Wang.
    Liu X, Liu Q, Yao X, Zhang M, Cui C, Li H, Liu D. Liu X, et al. Clin Infect Dis. 2021 Jul 15;73(2):352-353. doi: 10.1093/cid/ciaa1390. Clin Infect Dis. 2021. PMID: 33170206 Free PMC article. No abstract available.

References

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    1. McChesney EW, Banks WF Jr, Sullivan DJ. Metabolism of chloroquine and hydroxychloroquine in albino and pigmented rats. Toxicol Appl Pharmacol 1965; 7: 627–36. - PubMed
    1. McChesney EW, Banks WF Jr, Fabian RJ. Tissue distribution of chloroquine, hydroxychloroquine, and desethylchloroquine in the rat. Toxicol Appl Pharmacol 1967; 10:501–13. - PubMed
    1. McChesney EW. Animal toxicity and pharmacokinetics of hydroxychloroquine sulfate. Am J Med 1983; 75:11–8. - PubMed
    1. Fan J, Zhang X, Liu J, et al. Connecting hydroxychloroquine in vitro antiviral activity to in vivo concentration for prediction of antiviral effect: a critical step in treating COVID-19 patients. Clin Infect Dis 2020. doi:10.1093/cid/ciaa623. [Epub ahead of print]. - DOI - PMC - PubMed

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