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. 2021 Feb;48(2):e49-e71.
doi: 10.1111/1346-8138.15707. Epub 2020 Nov 27.

Outlines of the Japanese guidelines for the management of primary cutaneous lymphomas 2020

Mikio Ohtsuka  1 , Toshihisa Hamada  2 , Tomomitsu Miyagaki  3 , Takatoshi Shimauchi  4 , Kentaro Yonekura  5 , Eiji Kiyohara  6 , Hideki Fujita  7 , Koji Izutsu  8 , Kae Okuma  9 , Kazuhiro Kawai  10 , Hiroshi Koga  11 , Makoto Sugaya  12
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Outlines of the Japanese guidelines for the management of primary cutaneous lymphomas 2020

Mikio Ohtsuka et al. J Dermatol. 2021 Feb.

Abstract

Since the publication of the Japanese "Guidelines for the management of cutaneous lymphomas" in 2011, the World Health Organization (WHO) classification of hematolymphoid neoplasms and the WHO-European Organisation for Research and Treatment of Cancer classification for primary cutaneous lymphomas were updated and a number of novel systemic drugs for cutaneous T-cell lymphoma had been approved in Japan. In 2020, we revised the Japanese guidelines for the management of cutaneous lymphomas with consideration of the recent advances in the understanding of the pathophysiology and classification of cutaneous lymphomas together with the update of treatment strategies reflecting the advent of novel drugs. In addition to a brief explanation of epidemiology, diagnosis, staging system, prognosis and management of each subtype of cutaneous lymphomas, the recommendations for nine clinical questions regarding treatment options that can vary even among experts are also described. A systematic review process and determination of recommendations in answer to each clinical question have been performed in accordance with the Grading of Recommendations, Assessment, Development and Evaluation scheme by a multidisciplinary expert panel consisting of dermatologists, a hematologist and a radiation oncologist. In this article, we present the outlines of the revised Japanese "Guidelines for the management of cutaneous lymphomas".

Keywords: GRADE system; cutaneous lymphomas; guidelines; skin-directed therapies; systemic therapies.

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References

REFERENCES

    1. Sugaya M, Hamada T, Kawai K et al. Guidelines for the management of cutaneous lymphomas (2011): a consensus statement by the Japanese Skin Cancer Society - Lymphoma Study Group. J Dermatol 2013; 40: 2-14.
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    1. Willemze R, Cerroni L, Kempf W et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood 2019; 133: 1703-1714.
    1. Ohtsuka M, Izutsu K, Okuma K et al. Guidelines for the management of cutaneous lymphomas (2020). Jpn J Dermatol 2020; 130: 1347-1423. (article in Japanese).
    1. Gilson D, Whittaker SJ, Child FJ et al. British Association of Dermatologists and U.K. Cutaneous Lymphoma Group guidelines for the management of primary cutaneous lymphomas 2018. Br J Dermatol 2019; 180: 496-526.

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