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Review
. 2020 Dec;99(12):6422-6433.
doi: 10.1016/j.psj.2020.08.055. Epub 2020 Sep 8.

Treatment of tibial dyschondroplasia with traditional Chinese medicines: "Lesson and future directions"

Hui Zhang  1 , Yajing Wang  1 , Khalid Mehmood  2 , Yung-Fu Chang  3 , Zhaoxin Tang  4 , Ying Li  5
Affiliations
Review

Treatment of tibial dyschondroplasia with traditional Chinese medicines: "Lesson and future directions"

Hui Zhang et al. Poult Sci. 2020 Dec.

Abstract

Tibial dyschondroplasia (TD) is a metabolic tibiotarsal bone disease in rapidly growing birds throughout the world, which is characterized by gait disorders, reduced growth, and in an unrecoverable lameness in many cases. The short production cycle in chickens, long metabolism cycle in most of the drugs with the severe drug residue, and high treatment cost severely restrict the enthusiasm for the treatment of TD. Traditional Chinese medicine (TCM) has been used for the prevention, treatment, and cure of avian bone diseases. Previously, a couple of traditional Chinese medicines has been reported being useful in treating TD. This review will discuss the TCM used in TD and the alternative TCM to treat TD. Selecting a TCM approach and its pharmacologic effects on TD chickens mainly focused on the differentiation, proliferation, and apoptosis of chondrocytes, angiogenesis, matrix metabolism, oxidative damage, cytokines, and calcification of cartilage in tibia.

Keywords: chicken; pharmacologic effect; tibial dyschondroplasia; traditional Chinese medicine.

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Figures

Figure 1
Figure 1
The different changes of tibial metaphysis in tibial dyschondroplasia chickens.
Figure 2
Figure 2
Proximal end of tibial growth plate diagram of normal and TD chickens (modified from Leach and Monsonego-Ornan, 2007). Abbreviation: TD, tibial dyschondroplasia.
Figure 3
Figure 3
Model diagram of the influence of thiram on the development of tibia growth plate in broiler chickens.
Figure 4
Figure 4
Chemical structure of some traditional Chinese medicines used for TD treatment. Abbreviation: TD, tibial dyschondroplasia.
Figure 5
Figure 5
Mechanism of traditional Chinese medicines for improving bone remodeling in TD chickens. Abbreviation: TD, tibial dyschondroplasia.
See this image and copyright information in PMC

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