Review
Biochemical modulation of fluorouracil therapy in advanced colorectal cancer
Affiliations
- PMID: 3324921
Item in Clipboard
Review
Biochemical modulation of fluorouracil therapy in advanced colorectal cancer
Ann Acad Med Singap.
1987 Jul.
Abstract
Fluorouracil has been the mainstay of chemotherapy in colorectal cancer for many years. We report our experience using fluorouracil in combination with other drugs which may modulate the spectrum of activity. Patients have been treated with allopurinol and fluorouracil and with two schedules of methotrexate and fluorouracil. We discuss other possible approaches to modulate fluorouracil action.
Similar articles
-
Schedule-selective biochemical modulation of 5-fluorouracil: a phase II study in advanced colorectal cancer.Clin Cancer Res. 1995 Sep;1(9):955-60. Clin Cancer Res. 1995. PMID: 9816066 Clinical Trial.
-
Phase II study of sequential methotrexate and 5-FU combination in the treatment of advanced colorectal cancer.Cancer Treat Rep. 1986 Mar;70(3):419-20. Cancer Treat Rep. 1986. PMID: 3955557 No abstract available.
-
Selective modulation of 5-fluorouracil action in patients with colorectal carcinoma.Chemioterapia. 1985 Oct;4(5):377-82. Chemioterapia. 1985. PMID: 3878232
-
[Current studies of sequential methotrexate and 5-fluorouracil treatment in cancer chemotherapy].Gan To Kagaku Ryoho. 1988 Mar;15(3):409-17. Gan To Kagaku Ryoho. 1988. PMID: 3279912 Review. Japanese.
-
Chemotherapy of advanced cancer of the colon and rectum.Semin Oncol. 1991 Oct;18(5):443-61. Semin Oncol. 1991. PMID: 1925632 Review. No abstract available.
Cited by
-
Prediction of 5-fluorouracil cytotoxicity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo.Br J Cancer. 1989 Sep;60(3):303-9. doi: 10.1038/bjc.1989.275. Br J Cancer. 1989. PMID: 2789936 Free PMC article.
-
Enhanced 5-fluorouracil cytotoxicity and elevated 5-fluoronucleotides in the rat Walker carcinosarcoma following methotrexate pre-treatment: a 19F-MRS study in vivo.Br J Cancer. 1992 Mar;65(3):369-75. doi: 10.1038/bjc.1992.75. Br J Cancer. 1992. PMID: 1558790 Free PMC article.