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. 1987 Oct;31(10):1648-50.
doi: 10.1128/AAC.31.10.1648.

Energy-dependent efflux mediated by class L (tetL) tetracycline resistance determinant from streptococci

L M McMurry  1 , B H Park, V Burdett, S B Levy
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Energy-dependent efflux mediated by class L (tetL) tetracycline resistance determinant from streptococci

L M McMurry et al. Antimicrob Agents Chemother. 1987 Oct.

Abstract

The class L (TetL) tetracycline resistance determinant from streptococci specified resistance and an energy-dependent decreased accumulation of tetracycline in both Streptococcus faecalis and Escherichia coli. Using E. coli, we showed that the reduced uptake resulted from active efflux. The streptococcal class M determinant, known to render the protein synthesis machinery of S. faecalis resistant to tetracycline inhibition, did not alter tetracycline transport in either host.

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References

    1. Proc Natl Acad Sci U S A. 1972 Sep;69(9):2663-7 - PubMed
    1. Antimicrob Agents Chemother. 1987 Jul;31(7):1033-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3974-7 - PubMed
    1. J Bacteriol. 1981 Jan;145(1):494-502 - PubMed
    1. J Bacteriol. 1982 Mar;149(3):995-1004 - PubMed

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