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Review
. 2020 Oct 28:10:552236.
doi: 10.3389/fonc.2020.552236. eCollection 2020.

Emerging Roles and Potential Biological Value of CircRNA in Osteosarcoma

Jiamei Liu  1 , Liyu Yang  2 , Qin Fu  2 , Shengye Liu  2
Affiliations
Review

Emerging Roles and Potential Biological Value of CircRNA in Osteosarcoma

Jiamei Liu et al. Front Oncol. .

Abstract

Circular RNAs (circRNAs) are endogenous noncoding RNAs that are widely found in eukaryotic cells. They have been found to play a vital biological role in the development of human diseases. At present, circRNAs have been involved in the pathogenesis, diagnosis, and targeted treatment of multiple tumors. This article reviews the research progress of circRNAs in osteosarcoma (OSA) in recent years. The potential connection between circRNAs and OSA cell proliferation, apoptosis, metastasis, and chemotherapy sensitivity or resistance, as well as clinical values, is described in this review. Their categories and functions are generally summarized to facilitate a better understanding of OSA pathogenesis, and findings suggest novel circRNA-based methods may be used to investigate OSA and provide an outlook for viable biomarkers and therapeutic targets.

Keywords: circular RNAs; epithelial mesenchymal transition; metastasis; osteosarcoma; prognosis.

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Figures

Figure 1
Figure 1
The main mechanisms of circular RNA (circRNA) in tumor pathogenesis. (A) Formation process of circRNA by back-splicing cyclization in cells. (B) CircRNAs act as sponges of microRNAs (miRNAs) and subsequently affect target gene expression. (C) CircRNAs encode itself by translation of proteins in an internal ribosome entry site (IRES)-mediated way. (D) Recognition of exogenous circRNAs activates retinoic acid inducible gene I (RIG-I)-mediated autoimmunity. (E) CircRNAs are transported outside cells to regulate responses through exosomes or extracellular vesicles by membrane fusion and release.
Figure 2
Figure 2
Visualization of risk- and protection-associated circular RNAs (circRNAs).
See this image and copyright information in PMC

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