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. 2021 Jul;154(1):44-48.
doi: 10.1002/ijgo.13505. Epub 2020 Dec 31.

Storage conditions of oxytocin in a tropical climate in a low-income country

Ella Larissa de Vries  1 , Anne Antonia Cornelia van Tetering  1 , M Beatrijs van der Hout  1   2 , Luc Jozef Johannes Derijks  3 , Simon Peter Sseguya  4 , Imelda Namagembe  5 , Josaphat Byamugisha  6 , S Guid Oei  1   2
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Storage conditions of oxytocin in a tropical climate in a low-income country

Ella Larissa de Vries et al. Int J Gynaecol Obstet. 2021 Jul.

Abstract

Objective: To establish the storage conditions of oxytocin in a health facility in a low-income country with a tropical climate, as suboptimal storage may lead to ineffectiveness of drugs essential to prevent and treat postpartum hemorrhage.

Methods: At Mulago National Referral Hospital (28 000-33 000 deliveries/year) in Kampala, Uganda, temperature logging Safe-Rx cards were placed in boxes of oxytocin and in every known storage location. The route of the boxes through the hospital was tracked for 54 days, and storage conditions were observed.

Results: Oxytocin was stored within the recommended temperature range (2°C-8°C) 24% of the time. The average temperature measured within the oxytocin boxes was 18.2°C, with a minimum of -2.3°C and maximum of 30.4°C. Six out of twelve known storage places had a refrigerator, but not one location stored medication at the recommended temperature constantly. The average temperature in the storage places ranged from 9.5°C to 27.6°C, with a minimum temperature of 2.3°C and maximum of 30.9°C.

Conclusion: Oxytocin is not stored in the recommended temperature range for the majority of time. The presence of refrigerators does not ensure adherence to advised temperature storage conditions.

Keywords: low-income country; oxytocin; postpartum hemorrhage; quality; storage conditions; temperature monitoring; tropical climate; uterotonic agents.

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References

REFERENCES

    1. World Health Organization (WHO). WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage [WHO website]. 2012. https://apps.who.int/iris/bitstream/handle/10665/75411/9789241548502_eng.... Accessed June 19, 2019
    1. Say L, Chou D, Gemmill A, et al. Global causes of maternal death: a WHO systematic analysis. Lancet Glob Health. 2014;2(6):e323-e333.
    1. Begley CM, Gyte GM, Devane D, McGuire W, Weeks A. Active versus expectant management for women in the third stage of labour. Cochrane Database Syst Rev. 2015;3:CD007412.
    1. Ara B, Zaib-un-Nisa AF, Kakar P, Salam A, Aslam M. Atonic uterus; risk factors and management as a cause of primary postpartum hemorrhage. Professional Med J. 2014;21:1122-1127.
    1. Hogerzeil HV, Walker GJA, de Goeje MJ. Stability of injectable oxytocics in tropical climates: results of field surveys and simulation studies on ergometrine, methylergometrine and oxytocin [WHO website]. 1993. http://apps.who.int/medicinedocs/pdf/s2205e/s2205e.pdf. Accessed June 19, 2019

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